The transcription factor Foxh1 mediates Nodal signaling. The role of Foxh1 in left-right (LR) patterning was examined with mutant mice that lack this protein in lateral plate mesoderm (LPM). The mutant mice failed to express Nodal, Lefty2 and Pitx2 on the left side during embryogenesis and exhibited right isomerism. Ectopic introduction of Nodal into right LPM, by transplantation of left LPM or...

The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described. We show that Cripto also binds the proprotein convertases Furin and PACE4 and localizes Nodal processing at the cell surface. When coexpressed as in early embryonic cells, Crip...

The cornerstone of nodal spectral element methods is the co-location of the interpolation and integration points, yielding a diagonal mass matrix that is efficient for time-integration methods. On quadrilateral elements Legendre-Gauss-Lobatto points are both good interpolation and integration points but on triangles analogous points have not yet been found. In this paper we use a promising set ...

The integration of wind power into power grid will bring some impacts on the multiple subjects of electric power system. Economic impacts of wind power integration on multiple subjects of China’s electric power system were quantitatively assessed from Quasi-public goods property perspective in this paper. Firstly, the Quasi-public goods property of transmission services provided by power grid c...

A water distribution network is subjected to various abnormal conditions such as pipe breaks, pump failures, excessive demands etc. in the design period. Under such conditions, the network may not be able to meet required demands at desired pressures, and becomes deficient. Traditional network analysis assumes nodal demands to be satisfied and available nodal pressures are calculated. However, ...

Dog rose (Rosa canina) has been using as a rootstock for ornamental roses also it is one of the medicinal plants. It can be propagated under in vitro conditions. After removing chilling requirement of buds, axillary wood buds of dog rose were cut in three nodal positions (lower, middle and terminal) on the stem and then explants after decontamination, cultured on Murashige and Skoog medium (MS ...

In this paper we show how to extend the known algorithm of nodal analysis in such a way that, in the case of circuits without nullors and controlled sources (but allowing for both, independent current and voltage sources), the system of nodal equations describing the circuit is partitioned into one part, where the nodal variables are explicitly given as linear combinations of the voltage source...

Situs-specific organogenesis in the mouse results from leftward fluid flow in the node cavity and subsequent left-sided expression of Nodal in the lateral plate mesoderm (LPM). Nodal expression at the node is essential for the subsequent asymmetric Nodal expression in the left LPM, but the precise role of Nodal produced at the node has remained unknown. We have now investigated how the Nodal si...

Up to now most of the existing water supply network analyses have been based on demand-driven simulation models. These models assume that nodal outflows are fixed and are always available. However, this method of simulation neglects the pressure-dependent nature of demand that is characterized by changes in actual nodal outflows particularly during critical events like major mechanical or hydra...

This investigation is concerned with the use of an implicit integration method with adjustable numerical damping properties in the simulations of flexible multibody systems. The flexible bodies in the system are modeled using the finite element absolute nodal coordinate formulation (ANCF), which can be used in the simulation of large deformations and rotations of flexible bodies. This formulati...