Evidence is accumulating that commonly used pesticides are linked to decline of pollinator populations; adverse effects of three neonicotinoids on bees have led to bans on their use across the European Union. Developing insecticides that pose negligible risks to beneficial organisms such as honeybees is desirable and timely. One strategy is to use recombinant fusion proteins containing neuroact...

In an earlier neonatal porcine model of smoke inhalation injury (SII), immediate postinjury application of partial liquid ventilation (PLV) had dramatic beneficial effects on lung compliance, oxygenation, and survival over a 24-h period. To explore the efficacy of PLV following SII, we treated animals at 2 and 6 h after SII and followed them for 72 h. Pigs weighing 8-12 kg were sedated and phar...

The challenge of balancing the interests of patients with those of healthcare providers is increased when patients fail to show up for scheduled appointments. Overbooking appointments mitigates the lost productivity caused by no-shows but increases patient wait time and provider overtime. In this paper, simulation analysis is used to develop and test the performance of scheduling rules that are...

BACKGROUND Demand for endoscopic procedures scheduled with anesthesia is increasing and no-show to appointments carries significant patient health and financial impact, yet little is known about predictors of no-show. METHODS We performed a 16-month retrospective observational cohort study of patients scheduled for outpatient endoscopy with anesthesia at a county hospital serving the safety-n...

The presence of more than one non-severe pathogenic mutation in the same mitochondrial DNA (mtDNA) molecule is very rare. Moreover, it is unclear whether their co-occurrence results in an additive impact on mitochondrial function relative to single mutation effects. Here we describe the first example of a mtDNA molecule harboring three Leber's hereditary optic neuropathy (LHON)-associated mutat...

We develop a sequential clinical scheduling method for patients with general service time distributions. Patients are scheduled during a call-in period that precedes the scheduled consultation session. The session is divided into a set of time intervals called “slots”. When a patient calls, the scheduler assigns the patient to a suitable slot if one exists. Each scheduled patient has a probabil...

Objective The primary aim of this study is to compare tibial tuberosity-trochlear groove (TTTG) distance in patients with or without knee osteoarthritis. Additionally, the variability of tibial tubercle according to trochlear groove was evaluated. Materials and Methods In this retrospective cohort study, TTTG distance was measured with two different methods on magnetic resonance (MR) images. ...

In 1995, Malach et al. discovered an area whose fMRI BOLD response was greater when viewing intact, familiar objects than when viewing their scrambled versions (resembling texture). Since then hundreds of studies have explored this late visual region termed the Lateral Occipital Complex (LOC), which is now known to be critical for shape perception (James, Culham, Humphrey, Milner, & Goodale, 20...

Author's response to reviews: Revisions as follows: 1. Line numbering added and page breaks removed. 2. Page numbering added. 3. Title page edited to include email address of all authors in addition to institutions, and full postal address of submitting author 4. "Acronyms" changed to "list of abbreviations" and moved to after discussion section.

Disinfection of drinking water is regarded as one of the major public health achievements of the twentieth century, resulting in drastic reductions in diseases such as cholera and typhoid fever. However, potentially hazardous disinfection by-products (DBPs) can form when water treatment chemicals interact with other compounds in the water. In this issue of EHP, investigators assess the reproduc...