Macrophages, exhibiting high intrinsic accumulation and infiltration into tumor tissues, are a novel drug vehicle for directional drug delivery. However, the low drug-loading (DL) capacity and the drug cytotoxicity to the cell vehicle have limited the application of macrophages in tumor therapy. In this study, different drugs involving small molecular and nanoparticle drugs were loaded into int...

The isospin splitting of the in-medium $NN\rightarrow N\Delta$ cross sections in asymmetric nuclear medium are investigated framework one-boson exchange model by including $\delta$ and $\rho$ mesons. Our results show that correction factors $R=\sigma_{ NN\rightarrow N\Delta}^*/\sigma_{NN\rightarrow N\Delta}^{\text{free}}$ have $R_{pp \to n\Delta ^{++}} < R_{nn p\Delta ^{-}}$ $R_{NN N\Delta ^{+}...

In the title compound, C4H9Cl3N3O2P or CCl3C(O)NHP(O)(NHCH3)2, the P atom has a strongly distorted tetra-hedral geometry due to the formation of intermolecular strong hydrogen bonds involving the N atoms. In the crystal, N-H⋯O=P and N-H⋯O=C hydrogen bonds connect the mol-ecules into a two-dimensional array parallel to (100). An intra-molecular P⋯O contact [P⋯O = 2.975 (3) Å] is observed. The CC...

Chitosan is a cationic polysaccharide with great properties and so is considered as an attractive biopolymer. However, chitosan shows its antibacterial activity only in acidic environment and this restricts its uses. So water-soluble chitosan derivatives such as carboxymethyl chitosan could be good candidates for such biomedical applications. Modified chitosan with hydrophobic functional groups...