An autoerotic fatality due to mechanical compression of the neck by a sophisticated construction used for breath control games is reported. The presence of signs of methemoglobinemia as well as an empty "poppers" flask found beside the passed indicated the use of volatile nitrites to enhance sexual pleasure. It was assumed that vasodilatation had caused a sudden unconsciousness with consecutive...

Consumers are increasingly interested in purchasing meat products with low food additives content or even without the, since these kind of foodstuffs perceived as more natural and healthier. Nitrites the most commonly used industry to prevent growth pathogenic bacteria, keep red color (secondary effect on myoglobin = iron oxygen-binding), improve flavor. In this scenario, processors challenged ...

We thank Kruszelnicka and Surdacki (1) for their insightful comments on our recent article (2), which suggested a favorable metabolic effect of endothelial nitric oxide (NO) that stimulates the polarization of hepatic resident macrophages toward an anti-inflammatory M2 phenotype. Kruszelnicka and Surdacki ask whether the nitrate-nitrite pathway exerts beneficial metabolic effects in the liver. ...

The usefulness of nitroglycerin (glyceryl trinitrate) in relieving angina pectoris is undisputed: it has one of the clearest pharmacological effects in man. However, the mechanism of its action is not well understood (Gorlin, 1962; Case and Roven, 1963). In animal experiments the nitrites cause relaxation of smooth muscle, notably in the vessels, and an increased coronary flow can easily be dem...

Oxidative and nitrosative stress have been implicated in high-sodium diet (HSD)-related hypertensive renal injury. In this study, we investigated angiotensin II type 2-receptor-mediated renoprotection in obese Zucker rats fed HSD. Obese Zucker rats were fed normal sodium diet or HSD 4%, for 14 days, with/without angiotensin II type 2-receptor agonist C21, delivered subcutaneously via osmotic pu...

A patient with acute respiratory failure secondary to leptospirosis was treated with 40 and 90 volumes per million inhaled nitric oxide. His serum nitrogen oxide concentration (nitrates and nitrites combined) increased 13-fold. The mechanisms for the formation and elimination of nitrates are discussed.