The title compound, C20H18N2O·CH3CN, a perimidine deriv-ative, crystallized as an aceto-nitrile monosolvate. The planes of the naphthalene ring system and the meth-oxy-phenyl ring are oriented almost perpendicular to one another, with a dihedral angle of 87.61 (6)°. The conformation about the C=C bond is E. The hexa-hydro-pyrimidine ring has an envelope conformation, with the methine C atom as ...

In the title compound, [Cu(CH3CN)4](C2HO4)·0.5C2H2O4·0.5CH3CN, the Cu(I) ion is coordinated by the N atoms of four aceto-nitrile ligands in a slightly distorted tetra-hedral environment. The oxalic acid mol-ecule lies across an inversion center. The aceto-nitrile solvent mol-ecule is disordered across an inversion center and was refined with half occupancy. In the crystal, the hydrogen oxalate ...

We have extensively studied microbial metabolism of toxic compounds with a triple bond between carbon and nitrogen, such as nitriles [R–CN] . In the Pseudomonas chlororaphis B23 strain, nitrile is hydrated to amide by nitrile hydratase (NHase), followed by degradation to acid by amidase. This strain’s NHase was previously used for the industrial acrylamide production and is now used for the pro...

Ether-protecting functions at C-2 hydroxy groups have been found to play participating roles in glycosylations when the reactions are conducted in nitrile solvent mixtures. The participation mechanism is based on intramolecular interaction between the lone electron pair of the oxygen atom of the C-2 ether function and the nitrile molecule when they are positioned in a cis configuration. A 1,2-c...

Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase and amidase containing microbial whole cell catalyst, a number of racemic 1-arylmethyl- and 1-allyl-4-oxoazetidine-2-carbonitriles and carboxamides underwent efficient transformations under very mild conditions to produce enantiopure functionalized S-amide and R-acid products in excellent yields. While the nitrile hydratase showed...

A b-diketiminato n-butylmagnesium complex is presented as a selective precatalyst for the reductive hydroboration of organic nitriles with pinacolborane (HBpin). Stoichiometric reactivity studies indicate that catalytic turnover ensues through the generation of magnesium aldimido, aldimidoborate and borylamido intermediates, which are formed in a sequence of intramolecular nitrile insertion and...

The Suzuki-Miyaura coupling of aryl nitriles with aryl/alkenyl boronic esters is reported. With this method, the cyano group could be applied as a protecting group of arenes and finally as a leaving group to further construct polyaryl scaffolds.

The ammonolytic transfer dehydrogenation of amines has been identified as an efficient method for nitrile synthesis.