Muscará, Marcelo N., and John L. Wallace. Nitric Oxide. V. Therapeutic potential of nitric oxide donors and inhibitors. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1313–G1316, 1999.—Nitric oxide is a crucial mediator of gastrointestinal mucosal defense, but, paradoxically, it also contributes to mucosal injury in several situations. Inhibitors of nitric oxide synthesis and compounds...

Muscará, Marcelo N., and John L. Wallace. Nitric Oxide. V. Therapeutic potential of nitric oxide donors and inhibitors. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1313–G1316, 1999.—Nitric oxide is a crucial mediator of gastrointestinal mucosal defense, but, paradoxically, it also contributes to mucosal injury in several situations. Inhibitors of nitric oxide synthesis and compounds...

Under normal physiological conditions activation of nitric oxide synthases produces both nitric oxide and superoxide in equimolar concentrations (Figure 1). We propose a hypothesis that in hypoxia-reoxygenation injury this balanced co-production of nitric oxide and superoxide is disturbed and results in pathological effects. Specifically, under hypoxic conditions nitric oxide synthase is activa...

Nitric oxide is implicated in methamphetamine (METH)-induced neurotoxicity; however, the source of the nitric oxide has not been identified. Previous work has also revealed that animals with partial dopamine loss induced by a neurotoxic regimen of methamphetamine fail to exhibit further decreases in striatal dopamine when re-exposed to methamphetamine 7-30 days later. The current study examined...

introduction: toxoplasma gondii is an obligatory interacelullar parasite that infects nucleated cells in its intermediate hosts. the aim of the present study was to determine the effect of vitamin d3 on the multiplication of t. gondii in peritoneal macrophage of balb/c mice and nitric oxide production by macrophages.  methods: according to usage of vitamin d3 (one dose or seven doses) and infγ ...

Previous studies have demonstrated a role for the signalling agent nitric oxide in regulating preimplantation embryo development. We have now investigated the biochemical mode of action of nitric oxide in mouse embryos in terms of mitochondrial function and Ca2+ signalling. DETA-NONOate, a nitric oxide donor, decreased day 4 blastocyst cell number and oxygen consumption, consistent with a role ...

Airway nitric oxide production is decreased in cystic fibrosis. As growth hormone therapy has been shown to increase nitric oxide production in growth hormone-deficient patients, it may also affect nitric oxide production in patients with cystic fibrosis. The objective of the present study was to investigate the effect of growth hormone therapy on systemic and airway nitric oxide formation in p...

Immunosuppressants FK506 and cyclosporin A inhibit neurotoxicity of N-methyl-D-aspartate in primary cortical cultures, while having no effect on quisqualate- and kainate-mediated neurotoxicity. Rapamycin completely reverses the neuroprotective effect of FK506. Both FK506 and cyclosporin A inhibit NMDA-elicited/nitric oxide-mediated increases in cGMP levels in cortical cultures. FK506 has no eff...

It has been shown that nitric oxide is synthesized in the central nervous system as well as in vascular endothelial cells. Recently, it was reported that nitric oxide was involved in central cardiovascular regulation, baroreflex modulation, and involved in a reciprocal release with excitatory amino acids in the nucleus tractus solitarii of rats. The purpose of the present study was to investiga...

Bacterial lipopolysaccharide and some cytokines can activate macrophages to secrete nitric oxide. Macrophage-derived nitric oxide is a key cytotoxic factor for microbicidal and tumoricidal processes. We report here that a monoclonal antibody specific for beta interferon inhibited lipopolysaccharide-induced nitric oxide production in thioglycolate-elicited C3HeB/FeJ peritoneal macrophages and ma...