Encapsulation of iron oxide and gold nanoparticles into the bilayer structure transferrin-modified niosomes enables greatly enhanced contamination-free SERS-signals in vitro as well a dual-targeting functionality towards cancer cells.

The goal of the current study was to explore the potential benefits of Acitretin (Act) nanovesicular gel as a prospective antipsoriatic topical delivery system counteracting the drug challenges in terms of its extremely low aqueous solubility, instability, skin irritation, and serious systemic adverse effects. Act-loaded niosomes were successfully developed, entirely characterized, and optimize...

A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. One of the best options for successful drug delivery to the affected area of skin is the use of elastic vesicles (niosomes) which can be...

The aim of this paper is the preparation and characterization of drug delivery systems for a potential brain delivery by intranasal administration. It is possible to reach the central nervous system with alternative routes through which therapeutic agents can bypass the blood brain barrier: that is the nasal administration. Intranasal drug administration is non-invasive and it could be a promis...

Nystatin is bacterial originated polyene antifungal agent. The aim of the study is to develop the niosomal nystatin gel for transdermal administration. Formulations were developed using thin film hydration technique. Developed formulations were characterized for particle size, shape, % entrapment efficiency, in vitro drug release, etc. After analyzing the results, best formulation is optimized ...

Niosomes based on the nonionic surfactant Tween 80 and cholesterol modified with cationic surfactants (cetyltrimethylammonium bromide or its carbamate-bearing analog) were formed by thin film hydration method. Such a modification of niosomes provides an increase in their ? potential up to 60 mV, whereas hydrodynamic diameter particles is 100 nm remains nearly unchanged when content varied from ...