The chronic glaucoma with open angle is the second leading cause of blindness in the world. Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. Poor bioavailability of drugs from ocular dosage form is mainly due to the tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium....

Proniosomes are dry formulation of water soluble carrier particles that are coated with surfactant. They are rehydrated to form niosomal dispersion immediately before use on agitation in hot aqueous media within minutes. Proniosomes are physically stable during the storage and transport. Drug encapsulated in the vesicular structure of proniosomes prolong the existence of drug in the systematic ...

Drug delivery systems using colloidal particulate carriers such as liposomes and niosomes have distinct advantages over conventional dosage forms. However, there remain significant problems like instability in the general application of liposomes and niosomes for drug delivery. Proniosome have the potential to become a promising drug carrier in order to give stability to niosomal drug delivery ...

Objective(s): The purpose of the present study was to prepare and to evaluate a novel niosome as transdermal drug delivery system for propranolol hydrochloride and to compare the in vitro efficiency of niosome by either thin film hydration or hand shaking method. Materials and Methods: Niosomes were prepared by Thin Film Hydration (TFH) or Hand Shaking (HS) method. Propranolol niosomes were pre...

Abstract: Aim/Background: This research work intended to make use of prospective advantages niosomes for the improvement in topical delivery poorly soluble luliconazole. Materials and Methods: Luliconazole, an anti-fungal agent used treatment fungal infection, was successfully formulated as niosomal gel by using a polymer carbopol 934. The 32 full factorial statistical design employed means opt...

Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant-based multilamellar or unilamellar ves...