Nima Arkani-Hamed, Douglas P. Finkbeiner, Tracy R. Slatyer, and Neal Weiner School of Natural Sciences, Institute for Advanced Study, Princeton, New Jersey 08540, USA Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, Massachusetts 02138, USA Physics Department, Harvard University, Cambridge, Massachusetts 02138, USA Center for Cosmology and Particle Physics, Department o...

Bibi Shahin Shamsian*1, MD; Mohammad Thaghi Arzanian1, MD; Raheleh Kaviani1, MD; Samin Alavi1, MD; Mona Hedayat2,3, MD; Nima Rezaei2,3, MD, PhD 1. Department of Pediatric Hematology-Oncology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran, Iran 3...

Most researchers use visual communication symbols to achieve the purpose of information dissemination, which is also a very important marketing tool for current era packaging design. And technology make better product design has become one most means major enterprises sell their products and construct good brand image. In this paper, we deep CNN-based aesthetic classification method splash scre...

The genetic organization of two different 5-nitroimidazole (5-Ni) resistance genes was investigated: nimC and nimD from Bacteroides plasmids pIP419 and pIP421, respectively. The nimC gene (492 bp) and the nimD gene (495 bp) directed the synthesis of polypeptides with deduced molecular masses of 18.37 kDa and 18.48 kDa, respectively. The predicted proteins showed 67-83% identity and 78-91% simil...

Nek2 (NIMA-related kinase 2) is a serine-threonine kinase and human homolog of the mitotic regulator NIMA of Aspergillus nidulan. We reported the efficiency of Nek2 siRNA in several cancer xenograft models using cholangiocarcinoma, breast cancer and colorectal cancer. Pancreatic cancer is difficult to treat due to its rapid progression and resistance to chemotherapy. Novel treatments are urgent...

We investigated the metabolism of dimetridazole (1,2-dimethyl-5-nitroimidazole) (DMZ) by the resting cell method in a susceptible strain of Bacteroides fragilis and in the same strain containing the nimA gene, which conferred resistance to 5-nitroimidazole drugs. In both cases, under strict anaerobic conditions DMZ was metabolized without major ring cleavage or nitrate formation. However, one o...

The Aspergillus nimA gene encodes a Ser/Thr protein kinase which is required for mitosis, in addition to Cdc2, and which has been suggested to have a role in chromosomal condensation. In this study, we isolated a potential murine homologue of nimA, Nek2, which was shown to be expressed most abundantly in the testis of the adult tissues examined. Its expression in the testis was restricted to th...

Thank you for submitting your manuscript for consideration by The EMBO Journal. It has now been evaluated by three referees, whose reports are copied below. Although these reviewers point to the somewhat descriptive nature of the study, they nevertheless consider the main novel observation of apparently autonomous spindle checkpoint inactivation during prolonged mitotic arrest in Aspergillus po...

The molecular control of cell division and development in malaria parasites is far from understood. We previously showed that a Plasmodium gametocyte-specific NIMA-related protein kinase, nek-4, is required for completion of meiosis in the ookinete, the motile form that develops from the zygote in the mosquito vector. Here, we show that another NIMA-related kinase, Pfnek-2, is also predominantl...