This study examined the effects of nicotinamide on proliferation, differentiation, and energy metabolism in a primary culture of bovine adipocytes. After treatment of cells with 100-500 μM nicotinamide, cell growth was measured using 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), and cellular lipid content was assessed by Oil Red O staining and a triglyceride (TG) assay. Sev...

In this paper, we firstly demonstrate a simple and reproducible synthesis protocol to produce nicotinamide-stabilized gold nanoclusters (NAM-Au NCs) under mild conditions. The dominant role of the pH ligand metal ion molar ratio on formation these few atomic fluorescent NCs were proven. prepared show intensive blue-emission at 380 nm with two main lifetime components (4.7 6.7 ns), which refers ...

Background/Objective: Lung maturation has discrete dynamic shifts in metabolic derivatives that give rise to stage specific metabolite signatures. Components of one-carbon metabolism (OCM) are significantly increased the late saccular and alveolar while hyperoxia disrupts OCM during these lung developmental stages. We hypothesize disrupted metabolites immature vessel dependent formation thus co...

OBJECTIVES The purpose of this study was to develop and assess a rapid method for pyrazinamide resistance detection in Mycobacterium tuberculosis using nicotinamide in a colorimetric resazurin assay. METHODS We have tested M. tuberculosis isolates using nicotinamide in a 96-well format with the redox indicator resazurin (REMA) and compared results using the BACTEC 460-TB system with two conce...

Epidemiological surveys suggest an important role for niacin in the causes of Parkinson's disease, in that niacin deficiency, the nutritional condition that causes pellagra, appears to protect against Parkinson's disease. Absorbed niacin is used in the synthesis of nicotinamide adenine dinucleotide (NAD) in the body, and in the metabolic process NAD releases nicotinamide by poly(ADP-ribosyl)ati...

Purified PGH synthase when acting on arachidonic acid in the presence of reduced nicotinamide-adenine dinucleotide or reduced nicotinamide-adenine dinucleotide 3'-phosphate generated superoxide in burst-like fashion. In eight experiments using different batches of enzyme, the mean +/- SE rate of superoxide generation from 100 U of enzyme measured as the superoxide dismutase-inhibitable reductio...

In this paper, the possibility of using newly synthesized ionic liquid based on nicotinamide as a potential inhibitor copper corrosion in an acidic sulfate medium was investigated. Inhibition efficiency butyl-nicotinamide, [C4Nic]Br (pH=3) 0.1 mol/dm3 sodium sulphate solution analyzed potentiostatic polarization measurements and electrochemical impedance spectroscopy (EIS). It found that invest...

Methylation, a methyl group-consuming reaction, plays a key role in the degradation (i.e., inactivation) of monoamine neurotransmitters, including catecholamines, serotonin and histamine. Without labile methyl groups, the methylation-mediated degradation cannot take place. Although high niacin (nicotinic acid and nicotinamide) intake, which is very common nowadays, is known to deplete the body'...

Cutaneous immunity, which is a key defence against the development of skin cancers, is suppressed by even small doses of ultraviolet (UV) radiation. Preventing this UV-induced immunosuppression may therefore reduce the incidence of skin cancer. Nicotinamide (vitamin B3) has immune-protective and cancer-preventive effects against UV radiation in mice, and we have shown previously that topical ni...