•Cryo-EM ?3 adrenergic receptor structure complexes with mirabegron and G?s•Mirabegron adopts an elongated shape fits vertically within the pocket•Interactions essential for activation in orthosteric site are identified•The narrower exosite of accounts ?3AR-selectivity The ?3-adrenergic (?3AR) is predominantly expressed adipose tissue urinary bladder has emerged as attractive drug target treatm...

•Defined a consensus gene signature across three models of SARS-CoV-2 infection•Characterized subnetworks host proteins interacting with proteome•Integrated wide range COVID-19 and related data to build functional modules•Identified modules that can further the understanding This study is based on premise combining information from multiple layers result in new biologically interpretable associ...