نتایج جستجو برای: ngr
تعداد نتایج: 381 فیلتر نتایج به سال:
In schizophrenia, genetic predisposition has been linked to chromosome 22q11 and myelin-specific genes are misexpressed in schizophrenia. Nogo-66 receptor 1 (NGR or RTN4R) has been considered to be a 22q11 candidate gene for schizophrenia susceptibility because it encodes an axonal protein that mediates myelin inhibition of axonal sprouting. Confirming previous studies, we found that variation ...
A major barrier to regenerating axons after injury in the mammalian central nervous system is an unfavorable milieu. Three proteins found in myelin--Nogo, MAG, and OMgp--inhibit axon regeneration in vitro and bind to the glycosylphosphatidylinositol-anchored Nogo receptor (NgR). However, genetic deletion of NgR has only a modest disinhibitory effect, suggesting that other binding receptors for ...
The integrin αIIbβ3 on resting platelets can bind to immobilised fibrinogen resulting in platelet spreading and activation but requires activation to bind to soluble fibrinogen. αIIbβ3 is known to interact with the general integrin-recognition motif RGD (arginine-glycine-aspartate) as well as the fibrinogen-specific γ-chain dodecapeptide; however, it is not known how fibrinogen binding triggers...
A peptide containing Asn-Gly-Arg(NGR) sequence was synthesized and directly labeled with (99m)Tc. Its radiochemical characteristics, biodistribution, and SPECT imaging were evaluated in nude mice bearing human HepG2 hepatoma. Nude mice bearing HepG2 were randomly divided into 5 groups with 5 mice in each group and injected with ~7.4 MBq (99m)Tc-NGR. The SPECT images were acquired in 1, 4, 8, an...
Inhibitors of axonal regeneration in myelin are believed to be major contributors to the lack of regeneration in the adult CNS. Three of the four known myelin inhibitors, although very different structurally, interact with the same receptor, NgR. However, the absence of NgR has no effect on inhibition of neurite outgrowth in culture, and there is no improvement in CST regeneration in vivo. In a...
After injury to the central nervous system (CNS) in adults, axonal regeneration is confined, in part, by the inhibitory factors in CNS myelin, including Nogo-A protein, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMGP). These proteins, all bind to the same neuronal glycosylphosphatidylinositol-anchored receptors (NgR), and transduce inhibitory signals to cells ...
It is well known that Arginine-Glycine-Aspartic acid (RGD) and Asparagine-Glycine-Arginine (NGR) peptides preferentially bind to integrin receptors and aminopeptidase Nrespectively and these two receptors play important roles in angiogenesis. Therefore ketoprofenas a non-selective cox Inhibitor was conjugated with linear RGD and NGR to take advantageof targeting capability of these two motifs a...
It is well known that Arginine-Glycine-Aspartic acid (RGD) and Asparagine-Glycine-Arginine (NGR) peptides preferentially bind to integrin receptors and aminopeptidase Nrespectively and these two receptors play important roles in angiogenesis. Therefore ketoprofenas a non-selective cox Inhibitor was conjugated with linear RGD and NGR to take advantageof targeting capability of these two motifs a...
We introduce a novel procedure for studying the Hamiltonian formalism of new general relativity (NGR) based on mathematical properties encoded in constitutive tensor defined by premetric approach. derive canonical momenta conjugate to tetrad field and study eigenvalues Hessian tensor, which is mapped matrix with help indexation formulas. The heavily rely possible values free coefficients $c_i, ...
The threat to wildlife from chemical exposure exists regardless of the presence conservation boundaries. An issue exacerbated by use environmentally persistent insecticides for vector control and long-range transport legacy organic pollutants. In this comparative study between two important regions in South Africa, Kruger National Park (KNP) Ndumo Game Reserve (NGR), we assessed organochlorine ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید