نتایج جستجو برای: neutrophil activation

تعداد نتایج: 463084  

Journal: :iranian journal of basic medical sciences 0
maryam rameshrad department of pharmacology and toxicology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran student research committee, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran nasrin maleki-dizaji department of pharmacology and toxicology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran hamid soraya department of pharmacology, faculty of pharmacy, urmia university of medical sciences, urmia, iran negisa seyed toutounchi student research committee, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran abolfazl barzegari research center for pharmaceutical nanotechnology, tabriz university of medical sciences, tabriz, iran

objective(s): tlr-4 activates a number of inflammatory signaling pathways. also, ampk could be involved in anti-inflammatory signaling. the aim of this study was to identify whether stimulation of ampk could inhibit lps-induced tlr-4 gene expression in mice hearts. materials and methods: heart ampk activity and/or tlr-4 expression was stimulated in different mice groups, using respectively ip i...

2016
Yanlin Zhang Li Guan Jie Yu Zanmei Zhao Lijun Mao Shuqiang Li Jinyuan Zhao

BACKGROUND During the acute respiratory distress syndrome (ARDS), neutrophils play a central role in the pathogenesis, and their activation requires interaction with the endothelium. Extracellular histones have been recognized as pivotal inflammatory mediators. This study was to investigate the role of pulmonary endothelial activation during the extracellular histone-induced inflammatory respon...

Journal: :Blood 2007
Sven Jarius Peter Eichhorn Michael H Albert Stefan Wagenpfeil Manfred Wick Bernd H Belohradsky Reinhard Hohlfeld Dieter E Jenne Raymond Voltz

Intravenous immunoglobulin (IVIg) preparations are increasingly used for therapy of several neuroimmunologic diseases. IVIg therapy is considered safe, although serious side effects like aseptic meningitis, cerebral vasospasm, or ischemic encephalopathy have been reported. These side effects are frequently associated with neutrophilic pleocytosis in the cerebrospinal fluid (CSF), suggesting a n...

Journal: :The Biochemical journal 1998
P J Coffer N Geijsen L M'rabet R C Schweizer T Maikoe J A Raaijmakers J W Lammers L Koenderman

Although it is known that many stimuli can activate mitogen-activated protein kinases (MAPKs) and phosphatidylinositol 3-kinases (PI3K) in human neutrophils, little is known concerning either the mechanisms or function of this activation. We have utilized a selective inhibitor of MAPK kinase (MEK), PD098059, and two inhibitors of PI3K, wortmannin and LY294002, to investigate the roles of these ...

Journal: :Annals of the rheumatic diseases 1984
R Gale J V Bertouch T P Gordon J Bradley P J Roberts-Thomson

Membrane activation of human neutrophils by preformed immune complexes and heat aggregated human gammaglobulins was studied by chemiluminescence. Strong neutrophil activation was found with human-albumin rabbit-antialbumin complexes prepared at equivalence, with maximal activation occurring in slight antigen excess. Furthermore different preparations of heat aggregated gammaglobulin which were ...

Journal: :Current neurovascular research 2011
Helena Morrison Jennifer Frye Grace Davis-Gorman Janet Funk Paul McDonagh Gregory Stahl Leslie Ritter

After complement system (CS) activation, the sequential production of complement products increases cell injury and death through opsonophagocytosis, cytolysis, adaptive, and inflammatory cell responses. These responses potentiate cerebral ischemia-reperfusion (IR) injury after ischemic stroke and reperfusion. Activation of the CS via mannose binding lectin (MBL)-initiated lectin pathway is kno...

2015
Tadayuki Yago Brian G. Petrich Nan Zhang Zhenghui Liu Bojing Shao Mark H. Ginsberg Rodger P. McEver

Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia-reperfusion injury and other inflammatory disorders. Talin induces allosteric rearrangements in integrins that increase affinity for ligands (activation). Talin also links integrins to actin and other proteins that enable formation of adhesions. Structural studies have identified ...

Journal: :Shock 2012
Wolfgang G Junger Shawn G Rhind Sandro B Rizoli Joseph Cuschieri Maria Y Shiu Andrew J Baker Linglin Li Pang N Shek David B Hoyt Eileen M Bulger

Posttraumatic inflammation and excessive neutrophil activation cause multiple organ dysfunction syndrome (MODS), a major cause of death among hemorrhagic shock patients. Traditional resuscitation strategies may exacerbate inflammation; thus, novel fluid treatments are needed to reduce such posttraumatic complications. Hypertonic resuscitation fluids inhibit inflammation and reduce MODS in anima...

Journal: :Journal of applied physiology 2011
Stephen R Thom Ming Yang Veena M Bhopale Shaohui Huang Tatyana N Milovanova

Progressive elevations in circulating annexin V-coated microparticles (MPs) derived from leukocytes, erythrocytes, platelets, and endothelial cells are found in mice subjected to increasing decompression stresses. Individual MPs exhibit surface markers from multiple cells. MPs expressing platelet surface markers, in particular, interact with circulating neutrophils, causing them to degranulate ...

Journal: :Blood 1992
D E Daigneault K L Hartshorn L S Liou G M Abbruzzi M R White S K Oh A I Tauber

Although neutrophils are not viewed as a principal defense against influenza A virus (IAV) infection, their interactions are both complex and clinically relevant. Activation of the neutrophil is distinctive from that described for chemoattractants. To more fully characterize the pathway by which IAV stimulates the human neutrophil, we have examined its binding characteristics. First, inhibition...

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