944 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 6, June 2007 Septic shock developed in 4 (14.8%) of the 27 neutropenic patients with A. baumannii–associated bacteremia, and 2 (7.4%) of the 27 died (Table). However, we did not fi nd a statistically signifi cant association between death among patients with bacteremia caused by MDR A. baumanni (1 death) compared with death among...

Candidemia and invasive candidiasis (CIC) is associated with considerable morbidity and mortality, with a paucity of controlled data in neutropenic patients. A systematic review was conducted of available data for the treatment of CIC during neutropenia. A structured OVID search of multiple databases was performed. Data from randomized controlled trials of CIC and of empirical antifungal therap...

Three cases of neutropenic enterocolitis are described. This unusual condition occurs almost exclusively in neutropenic patients and has a fulminating course which is almost invariably fatal without surgical intervention. The lesion is centered on the caecum and hitherto its pathogenesis has been unclear, partly because most studies have been performed on material obtained at necropsy. In these...

Opportunistic infections caused by Candida tropicalis have been noted with increasing frequency in compromised patients. The pathogenicity of three isolates of C. tropicalis was studied in normal CD-1 mice, streptozotocin-induced diabetic mice, and cyclophosphamide-induced neutropenic mice. Lethal dose 50% endpoints and quantitative distribution of yeast cells in spleen, liver, and kidneys of m...

We describe a single institution experience with the use of granulocyte transfusion in children. This is a retrospective analysis of 45 collections of granulocyte units obtained by apheresis after priming with dexamethasone, infused into 17 children with severe neutropenic infections. Ten children survived the acute infection. Granulocyte transfusion is a useful adjunct to antimicrobials and gr...

Invasive aspergillosis (IA) is a serious opportunistic infection, which has increasingly been recognized as an emerging disease of non-neutropenic patients. In this group of patients, the diagnosis of IA can be challenging owing to the lack of specificity of symptoms, the difficulty in discriminating colonization from infection, and the lower sensitivity of microbiological and radiological test...

The increase use of intensive cytotoxic chemotherapy regimes achieve maximum antitumor activity, and cause of severe neutropenia. Neutropenic cancer patients are prone to infection when they become febrile. Bacterial infections are predominating among these patients. The bacterial infections in such patients are differ from institution to institution and is influenced by factors such a use of p...

BACKGROUND Neutropenic patients are vulnerable to a wide spectrum of infectious agents. The aim of this study was to determine the current frequency of bacterial infections in patients with nosocomial fever and neutropenia. METHODS In a retrospective study, the neutropenic patients' specimens with nosocomial fever were cultured on blood and MacConkey agar plates and evaluated at microbiology ...