The effects of sublethal amounts of the cationic dye, neutral red, upon the structure of pancreatic exocrine cells, and upon the mitochondria of renal distal tubule cells, have been studied with the electron microscope. It was found that neutral red is a cytoplasmic toxin which causes reproducible and characteristic changes in the ergastoplasm, the zymogen granules, the mitochondria, and possib...

Objective(s):Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. Telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. A relation between telomerase activity and resistance to apoptosis has been established. T...

Virulence of several species of enteropathogenic bacteria has been correlated with the ability of isolates to take up the dye Congo red. To determine whether Congo red uptake might be a useful marker for virulence of motile Aeromonas species, we examined 50 strains of diverse clinical origin on a medium containing 50 micrograms of Congo red per ml. All of the strains took up the dye to various ...

Hsia, Connie C. W., Robert L. Johnson, Jr., and Dipen Shah. Red cell distribution and the recruitment of pulmonary diffusing capacity. J. Appl. Physiol. 86(5): 1460–1467, 1999.—The distribution of red blood cells in alveolar capillaries is typically nonuniform, as shown by intravital microscopy and in alveolar tissue fixed in situ. To determine the effects of red cell distribution on pulmonary ...

In earlier studies of the mouse pancreas (1), it was found microscopically in saline preparations of living tissue that, within 30 min after the injection of an optimum dose of neutral red, small dye granules appeared in the cytoplasm of the acinar cells. With time, the granules became larger, reached a peak development at about 7 hr, then gradually diminished in size and number until, at about...

K+ released from exercising muscle via K+ channels needs to be removed from the interstitium into the blood to maintain high muscle cell membrane potential and allow normal muscle contractility. Uptake by red blood cells has been discussed as one mechanism that would also serve to regulate red blood cell volume, which was found to be constant despite increased plasma osmolality and K+ concentra...

objective(s):valproic acid (vpa), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. a relation between telomerase activity and resistance to apoptosis has been established. t...