PURPOSE To describe a case of bilateral herpes simplex keratitis accompanying chronic graft-versus-host disease (GVHD). DESIGN Observational case report. CASE REPORT An 11-year-old boy with myelocytic leukemia underwent allogeneic bone marrow transplantation. He developed symptoms of the skin, eyes, and mouth, and lip biopsy indicated chronic GVHD. Persistent keratitis with corneal filament...

purpose: to investigate confocal scan features of corneal subbasal nerve plexus and epithelial dendritic cells in herpes simplex keratitis (hsk) as compared to acanthamoeba keratitis (ak). methods: confocal scan records of patients with clinical and confocal microscopic features compatible with hsk and ak as well as confocal scan records of normal participants were reviewed. the density and mor...

purpose: to report two cases of bilateral bacterial keratitis as a sight-threatening complication following photorefractive keratectomy (prk) patients and findings: the first case was a 45-year-old man referred due to bilateral ocular pain and purulent discharge two days after bilateral prk. based on his clinical picture, smear and cultures from both corneal ulcers were taken with a diagnosis o...

purpose: to report a case of delayed corneal perforation secondary to topical diclofenac usage after myopic lasek and review of literature. patients and findings: a 25-year-old female with history of myopic lasek 2 months before referred to her surgeon with epithelial defect, stromal thinning and infiltration. she was treated with antimicrobial medications for infectious keratitis for one week....

PURPOSE To compare the relative diagnostic value of confocal microscopy and superficial corneal cultures in the diagnosis of Acanthamoeba keratitis by using clinical and microbiologic definitions of disease. METHODS Results of confocal microscopy, superficial corneal smear, and superficial corneal culture were analyzed for validity against 2 different microbiologic and a clinical composite st...

Herpetic keratitis is caused by herpes simplex virus (HSV) and is a common cause of corneal blindness. Following a primary ocular herpetic infection, latency of the virus occurs, followed by subsequent recurrences of herpetic keratitis. Such recurrences may lead to structural damage of the cornea. Recurrent herpetic keratitis is a common indication for corneal transplantation. Recurrences of he...

BACKGROUND Phlyctenular keratitis is a hypersensitivity reaction of the cornea, and a complication of eyelid margin disease in children and young adults. In this study, we compared the morphology of the meibomian glands in eyelids between phlyctenular keratitis patients and healthy young adults, using noncontact meibography. METHODS The study included 16 eyes of 13 patients diagnosed with phl...

Herpes simplex virus (HSV) keratitis is a common cause of ocular and visual morbidity. In this article, we systematically review published randomized clinical trials (RCTs) for HSV epithelial and stromal keratitis in order to establish a rational evidence-based foundation for treatment of these disorders. Articles for review were identified in the MEDLINE database from January 1, 1966, to May 3...

PURPOSE Idiopathic inflammation of the cornea, keratitis, has been proposed to result from an autoimmune process, but thus far no convenient animal model of keratitis exists. An attempt was made to establish an animal model for keratitis, to investigate possible autoimmune mechanisms. METHODS T-cell lines were established from lymph node cells removed from rats immunized with bovine corneal e...

Background & Aims: This study was carried out to determine the leading indications for corneal transplantation in Kerman province. Methods: Medical records of 186 patients underwent corneal transplantation during 3 years (2004-2006) in Shafa Medical Center were evaluated retrospectively. The initial diagnosis and causes of corneal grafting were recorded. Infectious keratitis (Bacterial, Fungal,...