نتایج جستجو برای: neuropathological changes
تعداد نتایج: 874847 فیلتر نتایج به سال:
The study reported in the present issue of the Journal of Alzheimer’s disease by Mizoroki et al. [8] concludes that the failure of treatment of transgenic mice with aluminum maltolate to induce Alzheimer’s-like neuropathological changes provides proof that aluminum is not a causative agent in the etiology of Alzheimer’s disease. In our opinion, this report by Mizoroki et al. fails to provide an...
Alzheimer's disease (AD) is a protein conformational disorder characterized by two major neuropathological features: extracellular accumulations of amyloid-β peptides in the form of plaques and intracellular tangles, consisting of hyperphosphorylated tau proteins. Several morphological and functional changes are associated with these lesions in the diseased brain, such as dendritic and synaptic...
31P nuclear magnetic resonance (NMR) studies were conducted on perchloric acid extracts of the brain of one control, two Huntington's disease (HD), one probable Alzheimer's disease (AD), and one AD patient. These studies demonstrated significant elevations (over control) in the levels of phosphomonoesters in all brain areas of the patients with HD and AD even in areas devoid of neuropathologica...
While the neuropathology of kuru is well defined, there are few data concerning the distribution of disease-related prion protein in peripheral tissues. Here we report the investigation of brain and peripheral tissues from a kuru patient who died in 2003. Neuropathological findings were compared with those seen in classical (sporadic and iatrogenic) Creutzfeldt-Jakob disease (CJD) and variant C...
The quotation above anticipates that loss of the proposed integrative functions of the claustrum might cause distinctive cognitive dysfunctions. Disconnection and degeneration of this structure might then contribute to cognitive and neuropsychiatric symptoms including those appearing in Alzheimer’s disease (AD). That the claustrum is important for at least some elements of the neuropsychologica...
BACKGROUND Prospective population-based neuropathological studies have a special place in dementia research which is under emphasised. METHODS A systematic review of the methods of population-based neuropathological studies of dementia was carried out. These studies were assessed in relation to their representativeness of underlying populations and the clinical, neuropsychological and neuropa...
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