Recently, a technique for facilitating rapid tracheal intubation — with the aid of nondepolarizing neuromuscular blocking drugs — has been described by Schwarz and colleagues (1985) using vecuronium. This method (priming) consists of the administration of a small dose of non-depolarizing blocker before induction, allowing sufficient time for the drug to reach the receptors and then the administ...

Three doses of salbutamol 125 micrograms iv were given, over 3.5 hr, to a 28-yr-old healthy, previously non-asthmatic man during thiopentone-O2/N2O-isoflurane anaesthesia for treatment and prophylaxis of bronchospasm. Force of contraction of the adductor pollicis was measured before and after the last two injections. Initially, the patient was given pancuronium, 5 mg. Salbutamol, 125 micrograms...

The hypothesis of this study was that diabetes-induced desensitization of rat soleus (SOL) and extensor digitorum longus (EDL) to non-depolarizing muscle relaxants (NDMRs) depends on the stage of diabetes and on the kind of NDMRs. We tested the different magnitude of resistance to vecuronium, cisatracurium, and rocuronium at different stages of streptozotocin (STZ)-induced diabetes by the EDL s...

background: increase in intraocular pressure (iop) following tracheal intubation during general anesthesia can be troublesome. we compared the influence of two muscle relaxants, cisatracurium and atracurium, on iop in patients undergoing general anesthesia. methods: this randomized, double-blind, comparative trial was conducted on 90 candidates for elective non-ophthalmic surgery under general ...

BACKGROUND This investigation determined the cardiopulmonary side effects of a novel nondepolarizing neuromuscular blocking drug with an ultrashort duration of action in anesthetized male beagles. METHODS The ED95 for GW280430A was first determined in four animals. These data were then used to guide bolus dosing in multiples of ED95 in six dogs instrumented for hemodynamic measurements as wel...