نتایج جستجو برای: neuromedin s

تعداد نتایج: 711493  

Journal: :Cancer letters 2009
Knut Ketterer Bo Kong Dietwalt Frank Nathalia A Giese Andrea Bauer Jörg Hoheisel Murray Korc Jörg Kleeff Christoph W Michalski Helmut Friess

Neuromedin U (NmU) is a bioactive peptide, ubiquitously expressed in the gastrointestinal tract. Here, we analyzed the role of NmU in pancreatic ductal adenocarcinoma (PDAC) pathogenesis. NmU and NmU receptor-2 mRNA were significantly overexpressed in PDAC and in metastatic tissues. NmU and NmU receptor-2 were localized predominantly in cancer cells. NmU serum levels decreased after tumor resec...

Journal: :The Journal of biological chemistry 1988
E Kislauskis B Bullock S McNeil P R Dobner

Recombinant DNA clones encoding the neurotensin/neuromedin N precursor protein have been isolated from both bovine hypothalamus cDNA and rat genomic libraries using a heterologous canine cDNA probe. Nucleotide sequence analysis of these clones and comparison with the previously determined canine sequence has revealed that 76% of the amino acid residues are conserved in all three species. The pr...

Journal: :Journal of clinical pathology 2004
W P ter Beek E S M Muller R A Van Hogezand I Biemond C B H W Lamers

BACKGROUND Gastrin releasing peptide (GRP) and neuromedin B are bombesin (BN)-like peptides involved in regulating motility and inflammation in the gastrointestinal tract, which may be useful in treating inflammatory bowel disease (IBD). Three bombesin-like peptide receptors have been reported, but no studies have investigated their localisation in normal and inflamed human intestine. AIM To ...

Journal: :Biological and Pharmaceutical Bulletin 2014

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