Luke Remage-Healey,1,3 Stephanie Dong,1 Nigel T. Maidment,2 and Barney A. Schlinger1 1Department of Integrative Biology and Physiology, and Laboratory of Neuroendocrinology, Brain Research Institute, and 2Hatos Center for Neuropharmacology, University of California, Los Angeles, Los Angeles, California 90095, and 3Neuroscience and Behavior Program, Center for Neuroendocrine Studies, University ...

The history of the management of craniopharyngiomas offers a comprehensive review of the exciting progress in neurosurgery, neuroimaging, neuroendocrinology and radiation oncology during the last century. In this historical note, we present the evolution in management of these most challenging of brain tumours, which, despite the substantial knowledge and expertise gained since the first attemp...

Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited. We aimed to identify the role of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) during tumor development and metastasis. Patients an...

The energy balance of an adult in stable conditions and eating ad libitum is in equilibrium over a long term as well as just during the 24 hrs period. The activity phase of an individual may be diurnal or nocturnal, depending on the species ; this phase corresponds to relative hyperphagia and storage of the metabolites ingested but not used to cover continuous energy expenditure. During the res...

911 One not working in rheumatology would probably find this book too technical for practical use (although the synopsis on systemic rheumatic diseases is excellent). Those working in this field-particularly those considering establishing a laboratory to perform these assays-would, however, find it of great utility. The latest issue in the biennial series Frontiers in Neuroendocrinology is high...

Acromegaly (ACM) is a chronic, progressive disorder caused by the persistent hypersecretion of GH, in the vast majority of cases secreted by a pituitary adenoma. The consequent increase in IGF1 (a GH-induced liver protein) is responsible for most clinical features and for the systemic complications associated with increased mortality. The clinical diagnosis, based on symptoms related to GH exce...