intermediateand high-grade tumors; (iii) the term ‘tumor’ (neuroendocrine tumor, NET) is meant for lowto intermediate-grade neoplasms, as previously defined either ‘carcinoid’ or ‘atypical carcinoid’; (iv) the word ‘carcinoma’ (neuroendocrine carcinoma, NEC) is meant only for high-grade neoplasms, as previously defined poorly differentiated carcinomas. This terminology is adopted by the ENETS 2...

This article reviews current concepts in pathologic classification of lung cancer based on 1999 World Health Organization (WHO)/International Association for the Study of Lung Cancer (IASLC) classification. Preinvasive lesions including squamous dysplasia/carcinoma in situ, atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia are discussed in additio...

We encountered a rare case in which a 14 mm ampullary tumor had both components of neuroendocrine carcinoma and adenocarcinoma, which caused acute pancreatitis. A Sixty-one-year-old woman was referred to our hospital for evaluation and treatment of pancreatitis due to an unknown cause. After various imaging examinations, the cause of pancreatitis was found to be a duodenal papillary tumor. We p...

The system of classification and terminology neuroendocrine neoplasms (NENs), updated in 2017 by AJCC 2019 WHO, is now recommended for general use. This article a review this with respect to NENs the digestive tract. Within new system, two categories were introdu­ced, differing morphology, clinical course treatment, as based on differentiation histological maturity grading (G). Among tract, wel...

Neuroendocrine tumors are rarely seen in the breast. They are commonly located in the gastrointestinal tract and the lungs. These tumors of the breast may be purely neuroendocrine or neuroendocrine diff erentiated. Some breast tumors may have neuroendocrine foci. The clinical signifi cance of these tumors are unclear. However, they are thought to have no relation with the prognosis and patient ...

We present here a case of a 42-year-old woman diagnosed with primary neuroendocrine carcinoma of the breast (NECB). We discuss the importance of histological criteria for primary neuroendocrine mammary carcinoma, established by WHO in 2003 and 2012. After an overview of different cases of primary neuroendocrine carcinoma of the breast published in the literature, we present information about di...

Primary neuroendocrine carcinoma of the breast is a very rare malignant tumor. There are not many cases reported in the English literature since it was first documented in 1983. Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce. Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masqueradin...

Large cell neuroendocrine carcinoma of the urinary bladder is rare. In the last five years, we have had the opportunity to see this type of cancer in an 88-year-old and in a 66-year-old males. In both cases, transurethral resection of carcinoma of the bladder was carried out. In the first case, urothelial carcinoma was detected and deeper in the bladder wall, large cell neuroendocrine carcinoma...

BACKGROUND Few studies on how to diagnose pulmonary neuroendocrine tumors through morphometric analysis have been reported. In this study, we measured and analyzed the characteristic parameters of pulmonary neuroendocrine tumors using an image analyzer to aid in diagnosis. METHODS Sixteen cases of typical carcinoid tumor, 5 cases of atypical carcinoid tumor, 15 cases of small cell carcinoma, ...

Adenoneuroendocrine carcinoma is a very rare form of cervical carcinoma that includes both endocrine and exocrine components. In general terms, these carcinomas progress aggressively and show early metastases due to the neuroendocrine component. The most important criteria related to prognosis is the stage of the disease. Without clearly determined therapeutic protocols this carcinoma is genera...