BACKGROUND To date, periorbital melanosis is an ill-defined entity. The condition has been stated to be darkening of the skin around the eyes, dark circles, infraorbital darkening and so on. AIMS This study was aimed at exploring the nature of pigmentation in periorbital melanosis. METHODS One hundred consecutive patients of periorbital melanosis were examined and investigated to define per...

Soft palatal melanosis can be detected by visual inspection during routine physical examination or even personally in a mirror. The aim of this study was to evaluate the association between squamous cell neoplasia in the upper aerodigestive tract (UAT) and soft palatal melanosis. We reviewed digitized records of high-quality endoscopic images of the soft palate of 1786 Japanese alcoholic men wh...

Melanosis coli is associated with an increased risk of colorectal tumors but is not agreed to be a precancerous lesion. The condition has been associated with the ingestion of anthracene laxatives and is believed to be caused by increased epithelial apoptosis. Although melanosis coli is a frequent finding in colonic biopsies and resection specimens, to our knowledge severe jet black melanosis c...

BACKGROUND The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time. OBJECTIVE To describe a transformation of a mucosal melanosis into melanoma. METHODS ...

BACKGROUNDS AND AIMS The association of melanosis coli with the development of colorectal polyps remains uncertain. METHODS From a total of 18263 patients who had received colonoscopy in our hospital, 219 with melanosis coli cases and 438 controls matched by age and sex (at 1:2 ratio) were included in this study. The association of incidence, number, location, and pathology of colorectal neop...

Periorbital melanosis (under eye dark circles) is an often idiopathic cosmetically disturbing condition that is poorly responsive to currently available treatment modalities. We present the case of a 48-year-old man (skin phototype V) with significant idiopathic periorbital melanosis and who had good to excellent reduction in periorbital melanosis with the new DermaFrac™, which combines microne...

CASE REPORT A 31-year-old half Thai, half white woman presented to the dermatology clinic for evaluation of multiple disfiguring pigmented papules and nodules covering her entire body. Her dermatologic history was significant for a GCMN treated with curettage at age 2. The patient reported that she was born with many pigmented papules and nodules, which increased in number throughout her life. ...