Several stem cell sources persist in the adult human body, which opens the doors to both allogeneic and autologous cell therapies. Tooth tissues have proven to be a surprisingly rich and accessible source of neural crest-derived ectomesenchymal stem cells (EMSCs), which may be employed to repair disease-affected oral tissues in advanced regenerative dentistry. Additionally, one area of medicine...

The spinal cord injury (SCI) refers to a condition that the damage to the spinal cord causes neurologic dysfunction. In the case of neurologic dysfunction owing to SCI, its recovery is desperate, and the pathological condition appears as the incompetence of the body. Originally, neural axons can expand even after injury and produce a recovery of the neuronal network [1]. However, the SCI leads ...

Recent advances in stem cell biology have provided new insights that may lead to the development of regeneration therapy in the central nervous system to replenish lost neurons and to reconstitute neural circuits. The strategies for regeneration can be classified into two approaches: i) activation of endogenous neural stem cells and ii) transplantation of donor cells to replace lost cells. In t...

BACKGROUND Neurotrophins are important regulators for neural development and regeneration. Nerve growth factor (NGF) therapy has been tested in various models of neural injury and degeneration. However, whether NGF can reach target tissues and maintain effective concentration for a certain period of time remains uncertain. To facilitate neural regeneration, we investigate the possibility of com...

EURAL degeneration resulted from various traumas and diseases, represents a preponderance of health problem all over the world. Although various cell therapies and implants have been investigated, repairing damaged nerves and achieving full functional recovery are still challenging. For instance, autografts are usually difficult to collect sufficient donor nerves from patients in addition to po...

OBJECTIVE Cranial nerve injury involves loss of central neural cells in the brain stem and surrounding support matrix, leading to severe functional impairment. Therapeutically targeting cellular replacement and enhancing structural support may promote neural regeneration. We examined the combinatorial effect of neural precursor cells (NPC) and self assembling peptide (SAP) administration on ner...

Embryogenesis, regeneration and cell differentiation in microbiological entities are influenced by mechanical forces. Therefore, development of mechanical properties of these materials is important. Neural network technique is a useful method which can be used to obtain cell deformation by the means of force-geometric deformation data or vice versa. Prior to insertion in the needle injection pr...

background: the failure of regeneration after spinal cord injury (sci) has been attributed to axonal demyelination and neuronal death. cellular replacement and white matter regeneration are both necessary for sci repair. in this study, we evaluated the co-transplantation of olfactory ensheathing cells (oec) and embryonic stem (es) cell-derived motor neurons (esmn) on contused sci. methods: oec ...

Brain regeneration in planarians is mediated by precise spatiotemporal control of gene expression and is crucial for multiple aspects of neurogenesis. However, the mechanisms underpinning the gene regulation essential for brain regeneration are largely unknown. Here, we investigated the role of the miR-124 family of microRNAs in planarian brain regeneration. The miR-124 family (miR-124) is high...