BACKGROUND Mass spectrometry (MS) is being introduced into a large number of clinical laboratories. It provides specificity because of its ability to monitor selected mass ions, sensitivity because of the enhanced signal-to-noise ratio, and speed because it can help avoid the need for intensive sample cleanup and long analysis times. However, MS is not without problems related to interference, ...

Environmental monitoring involves several steps such as sampling, sample handling and sample transportation to specialized laboratories, sample preparation and analysis. Traditional environmental monitoring approaches are based on discrete sampling methods followed by laboratory analysis. These approaches do not improve our understanding of the natural processes governing chemical species behav...

In this paper, a highly sensitive graphene-based multiple-layer (BK7/Au/PtSe2/Graphene) coated surface plasmon resonance (SPR) biosensor is proposed for the rapid detection of novel Coronavirus (COVID-19). The sensor was modeled on basis total internal reflection (TIR) technique real-time ligand-analyte immobilization in sensing region. refractive index (RI) region changed due to interaction di...

In this report, poly(1,8-diaminonaphthalene) as a molecularly imprinted polymer (MIP) coated on gold nanoparticles (nano Au) dispersed ITO electrode was prepared. While nano Au strongly enhance the Raman signal of analyte, MIP layer allows to selective trap and enrich analyte molecules close surface. fact, by building matrix around target molecules, in case is rhodamine B then extraction we can...

Detection of molecules involved with the functioning of living things impacts a broad spectrum of applications from pathogen detection to drug development and biochemically-guided medical care . Faced with the complexity of molecular level interactions that typically characterize biological molecules, sensing technologies win and lose: on one hand they can exploit this richness to realize the s...

In the present study, a new biosensor for 5-Fluorouracil was described using modified goldelectrode and Fast Fourier transform square wave voltammetry (FFT SWV). Calf thymus DNAimmobilization was on a gold electrode decorated with polyaniline and gold nanoparticles. Theelectrochemical characteristics of the electrodes were investigated by cyclic voltammetry, andelectroch...

Reagent-free electronic biosensors capable of analyzing disease markers directly in unprocessed body fluids will enable the development simple & affordable devices for personalized healthcare monitoring. Here we report a powerful and versatile nucleic acid-based reagent-free sensing system. The signal transduction is based on kinetics an electrode-tethered molecular pendulum—a rigid double stra...

Abstract Ca isotopes have gained increasing interest as a diagnostic tool for bone diseases due to the variations in abundances consequence of changes bone-mineral balance. Optimized Ca/matrix separation prior analysis is prerequisite reliable isotope ratio measurements complex biological matrices such blood, serum, or urine. The online analyte/matrix by ICP-MS enables direct assessment elution...

Chemical sensing using optical fibers is often challenging, as it is generally difficult to achieve strong interaction between the guided light and the analyte at the wavelength of interest for performing the detection. Despite this difficulty, many schemes exist (and can be found in the literature) for point chemical fiber sensors. However, the challenge increases even further when it comes to...

INTRODUCTION 6-Mercaptopurine (6MP) is an important chemotherapeutic drug in the conventional treatment of childhood acute lymphoblastic leukemia (ALL). It is catabolized to 6-thiouric acid (6TUA) through 8-hydroxo-6-mercaptopurine (8OH6MP) or 6-thioxanthine (6TX) intermediates. METHODS High-performance liquid chromatography (HPLC) is usually used to determine the contents of therapeutic drug...