نتایج جستجو برای: nestin

تعداد نتایج: 2197  

2014
Diana Klein Nicole Meissner Veronika Kleff Holger Jastrow Masahiro Yamaguchi Süleyman Ergün Verena Jendrossek

Tumor vessels with resistance to anti-angiogenic therapy are characterized by the normalization of the vascular structures through integration of mature pericytes and smooth muscle cells (SMC) into the vessel wall, a process termed vessel stabilization. Unfortunately, stabilization-associated vascular remodeling can result in reduced sensitivity to subsequent anti-angiogenic therapy. We show he...

2016
Hilal Erinanc Erzat Toprak

Background: Pathogenesis of endometrial polyps have not been fully understood however the increased proliferation of blood vessells and fibrosis may play an important role in the pathogenesis of endometrial polyps. Vascular endothelial growth factor (VEGF) is a a key regulator of angiogenesis and vascular function. Nestin is another molecule which has been reported to be associated with the pro...

Journal: :Turkish neurosurgery 2015
Vasiliki Galani George A Alexiou Georgios Miliaras Efthymios Dimitriadis Elena Triantafyllou Aggeliki Galani Anna Goussia Panagiotis Kanavaros Theoni Trangas

AIM Meningiomas are one of the most common benign intracranial tumors, making up nearly one third of all primary intracranial tumors. The majority of meningiomas have benign histological features and total resection is associated with favourable prognosis. Atypical and malignant meningiomas are associated with increased risk of recurrence. In the present study we set out to investigate the role...

Journal: :Mechanisms of Development 2000
Jing Yang Wei Bian Xiang Gao Leping Chen Naihe Jing

Nestin is an intermediate filament protein, which is expressed predominantly in the developing central nervous system and skeletal muscles. In situ hybridization revealed that mouse nestin mRNA is in the optic stalk at 9.0 days post coitus (dpc) and in the lens vesicle at 10.0 dpc. From 14.5 dpc onward, nestin transcripts appear in lens fibers and neuroretina. Immunohistochemistry showed that n...

Journal: :Cell 2014
Darjus F. Tschaharganeh Wen Xue Diego F. Calvisi Matthias Evert Tatyana V. Michurina Lukas E. Dow Ana Banito Sarah F. Katz Edward R. Kastenhuber Susann Weissmueller Chun-Hao Huang Andre Lechel Jesper B. Andersen David Capper Lars Zender Thomas Longerich Grigori Enikolopov Scott W. Lowe

The p53 tumor suppressor coordinates a series of antiproliferative responses that restrict the expansion of malignant cells, and as a consequence, p53 is lost or mutated in the majority of human cancers. Here, we show that p53 restricts expression of the stem and progenitor-cell-associated protein nestin in an Sp1/3 transcription-factor-dependent manner and that Nestin is required for tumor ini...

Journal: :Neuroreport 2014
Chun Guang Di Andy Peng Xiang Lei Jia Jun Feng Liu Bruce T Lahn Bao Feng Ma

Nestin knockout leads to embryonic lethality and self-renewal deficiency in neural stem cells (NSCs). However, how nestin maintains self-renewal remains uncertain. Here, we used the dosage effect of nestin in heterozygous mice (Nes+/-) to study self-renewal of NSCs. With existing extracellular signaling in vivo or in vitro, nestin levels do not affect proliferation ability or apoptosis when com...

2013
Sumiyuki Mii Fuminari Uehara Shuya Yano Benjamin Tran Shinji Miwa Yukihiro Hiroshima Yasuyuki Amoh Kensei Katsuoka Robert M. Hoffman

We have previously reported that hair follicles contain multipotent stem cells which express nestin. The nestin-expressing cells form the hair follicle sensory nerve. In vitro, the nestin-expressing hair follicle cells can differentiate into neurons, Schwann cells, and other cell types. In the present study, the sciatic nerve was excised from transgenic mice in which the nestin promoter drives ...

Journal: :Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2008
Ping-lin Yang Xi-jing He Hao-peng Li Bin-shang Lan Dong Wang Guo-yu Wang Si-yue Xu Yi-heng Liu

OBJECTIVE To observe the expressions of nestin and glial fibrillary acidic protein (GFAP) and their association with reactive astrocytes following spinal cord injury in adult rats. METHODS Adult rats with compression injury of the spinal cord were divided into 7 groups (n=6) and examined at 1, 3, and 5 days and at 1, 2, 4 and 8 weeks after the injury. The recovery of the locomotor function af...

2015
Svenja Thies Martina Friess Lukas Frischknecht Dimitri Korol Emanuela Felley-Bosco Rolf Stahel Bart Vrugt Walter Weder Isabelle Opitz Alex Soltermann Sumitra Deb

BACKGROUND The epithelioid and sarcomatoid histologic variants of malignant pleural mesothelioma (MPM) can be considered as E- and M-parts of the epithelial-mesenchymal transition (EMT) axis; the biphasic being an intermediate. EMT is associated with an increase of stem cell (SC) traits. We correlated the neural crest SC marker nestin and the EMT marker periostin with histology, type of neo-adj...

Journal: :Journal of Experimental & Clinical Cancer Research : CR 2008
Mingyu Zhang Tao Song Liang Yang Ruokun Chen Lei Wu Zhuanyi Yang Jiasheng Fang

AIM Gliomas represent the most frequent neoplasm of the central nervous system. Unfortunately, surgical cure of it is practically impossible and their clinical course is primarily determined by the biological behaviors of the tumor cells. The aim of this study was to investigate the correlation of the stem cell markers Nestin and CD133 expression with the grading of gliomas, and to evaluate the...

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