Peripheral nerves were first distinguished from tendons by Herophilus in 300 BC. By meticulous dissection he traced nerves to the spinal cord, demonstrating the continuity of the nervous system(1). In 900 AD, Rhazes made the first clear reference to nerve repair. However, not until 1795 did Cruikshank demonstrate nerve healing and recovery of distal extremity function after repair. In the early...

background: compressive neuropathy of median nerve is relatively common but development of an hourglass like constriction is a rare phenomenon. the purpose of this study is to show morphologic changes of median nerve in advances carpal tunnel syndrome. methods: eighty patients with thenar atrophy, anesthesia and paresthesia of first, second and third finger and severe changes of emg‑ncv were ch...

Peripheral nerve injury (PNI) is common and, unlike damage to the central nervous system injured nerves can effectively regenerate depending on location and severity of injury. myelinating glia, Schwann cells (SCs), interact with various in around site are important for debris elimination, repair, regeneration. Following PNI, Wallerian degeneration distal stump rapidly initiated by damaged axon...

End-to-end suture of nerves and autologous nerve grafts are the 'gold standard' for repair and reconstruction of peripheral nerves. However, techniques such as sutureless nerve repair with tissue glues, end-to-side nerve repair and allografts exist as alternatives. Biological and synthetic nerve conduits have had some success in early clinical studies on reconstruction of nerve defects in the h...

BACKGROUND Complex peripheral nerve injuries of the hand include at least 300,000 cases per year in Europe. The standard treatment involves a microsurgical end-to-end suture of traumatic sensory nerve lesions of the hand without a gap. The objective of this study protocol is to evaluate whether the additional use of a chitosan nerve tube in primary repair of traumatic sensory nerve lesions of t...

the overall goal of this study was to identify the appropriate biomaterials able to facilitate the regeneration in rat's injured adult spinal cord. acute damage to axons is manifested as a breach in their membranes, ionexchange distortion across the compromised region, local depolarization and even conduction block. it would be of particular importance to interrupt the progress of events h...