The Effect of Descurainia Sophia Seed Extract on Nephrotoxicity Markers Induced by Acetaminophen in Mice

Hydrogen Sulfide (H2S) prevents and treats a variety of disorders via its cytoprotective effects. However, the effects of H2S on rats with cisplatin (CP) nephrotoxicity are unclear. The aim was to study the effects of H2S on rats with CP nephrotoxicity. Thirty male Sprague-Dawley rats were divided into three groups: control group, nephrotoxic group received sing...

Aim: Colistin (Col) is an agent used in the treatment of multidrug-resistant gram-negative (MDRGN) bacterial infections. This drug has been administered with a loading dose recent years to provide rapid clinical response and therapeutic blood levels. In our study, we aimed evaluate whether there relationship between efficacy Col treatment, mortality, microbiological clearance during nephrotoxic...

Bromobenzene (BB) is known to pose a serious threat human health. We previously demonstrated that BB showed chronotoxicity, is, daily fluctuations in the severity of hepatotoxicity induced mice. Although mild nephrotoxicity, fluctuation was not observed this toxicity. This might be attributed fact BB-induced chronotoxicity only liver and kidneys damage caused by prominent liver, masking nephrot...

Iodinated contrast agents are usually classified based upon their osmolality--high, low, and isosmolar. Iodinated contrast agents are also nephrotoxic in some but not all patients resulting in loss of glomerular filtration rate. Over the past 30 years, nephrotoxicity has been linked to osmolality although the precise mechanism underlying such a link has been elusive. Improvements in our underst...

Cisplatin (cis-diamine-dichloroplatinum (II), CDDP) is a prominent member of the effective broad-spectrum antitumor drugs. However, its clinical usage restricted due to serious side effects particularly nephrotoxicity. The vulnerability kidney CDDP almost certainly related primary role in excretion drug as intact and platinum containing products are excreted mainly urine. There correlation betw...

Renal physiology, biochemistry, and anatomy are reviewed. For the most part, those aspects of these disciplines will be discussed which relate directly to the question of the evaluation of nephrotoxicity. In addition, emphasis is placed on those procedures and techniques which are useful in the evaluation of nephrotoxicity. A detailed discussion of histological and anatomical considerations is ...

Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial fibrosis and tubular atrophy, which impairs long-term allograft survival. The mineralocorticoid hormone aldosterone induces fibrosis in numerous organ...

Background: Nephrotoxicity is one of the major side-effects of cisplatin that has been seen in about 20% of treated patients. The aim of this study was to assess the effectiveness of a forced hydration protocol comprised of isotonic saline, potassium chloride (KCl) and magnesium sulfate (MgSO4) on prevention of cisplatin nephrotoxicity. Methods: This cross sectional prospective study was perfor...

Gentamicin may cause acute kidney injury. The pathogenesis of gentamicin nephrotoxicity is unclear. Autophagy is a highly conserved physiological process involved in removing damaged or aged biological macromolecules and organelles from the cytoplasm. The role of autophagy in the pathogenesis of gentamicin nephrotoxicity is unclear. The miniature pigs are more similar to humans than are those o...