PURPOSE Contrast agents administered in diagnostic imaging or interventional procedures of clinical radiology may cause contrast-induced nephropathy (CIN). Preventive measures against CIN involve pharmaceutical pretreatments, such as N-acetylcystein (NAC) or calpain, but alternative medicines can also be helpful. This study aims to assess the prospects of a natural compound, propolis, as a pote...

Rev Esp Cardiol. 2010;63(4):488-502 501 factor for a composite variable of contrast-induced nephropathy, need for dialysis, and mortality during the stay in the coronary unit. Although the results seem clear, not all studies have been favorable to the use of N-acetylcysteine in preventing contrast nephropathy, with sometimes conflicting results.2-5 For example, in a clinical trial in China4 whi...

BACKGROUND The COL4A3-/- mouse serves as animal model for progressive renal fibrosis. Using this animal model, the present study investigates the nephroprotective effects of Paricalcitol versus Calcitriol alone and on top of ACE-inhibitor therapy. METHODS Eighty six mice were divided into six groups: (PC) with Paricalcitol 0.1 mcg/kg, (CA) Calcitriol 0.03 mcg/kg (dose equipotent), (PLAC) vehi...

Although cisplatin is an effective anti-cancer agent that is widely used for treating various types of malignant solid tumors, the nephrotoxicity induced by cisplatin severely limits its clinical application. The present study was designed to explore the potential protective effect of ginsenoside Rg5, a rare ginsenoside generated during steaming ginseng, on cisplatin-induced nephrotoxicity in a...

Kidney diseases are a major problem of worldwide proportions and renal damage is very common since kidney has the capacity to excrete toxic substances. A phytotherapeutic approach to modern drug development can provide many invaluable drugs from traditional medicinal plants. Search for pure photochemical as drugs is time consuming and expensive. Numerous plants and polyherbal formulations are u...