Lupus Nephritis is a severe, organ-threatening manifestation of Systemic Erythematosus (SLE). The current standard care in the treatment lupus nephritis limited to broad-spectrum immunosuppressants, which have significant concerns short- and long-term toxicity. With traditional approaches, kidney survival patient outcomes remained suboptimal. Robust research therapeutics has resulted developmen...

BACKGROUND Polyoma virus type BK (BKV) nephritis has emerged as an important cause of renal allograft dysfunction and graft failure. Its diagnosis is contingent on the invasive procedure of allograft biopsy. A noninvasive diagnostic test for BKV nephritis could improve clinical outcome. METHODS We obtained 25 urine specimens from 8 renal allograft recipients with biopsy-confirmed BKV nephriti...

INTRODUCTION S hunt nephritis is a rare complication mostly described in the setting of chronic infection of ventriculoatrial (VA) shunts inserted for the treatment of congenital or acquired hydrocephalus. The diagnosis of shunt nephritis is challenging and may be overlooked. We report a case of successfully treated shunt nephritis and pyogenic spondylitis with positive antiproteinase 3 antineu...

We report a case of mesangial proliferative glomerulonephritis with interstitial nephritis associated with multicentric Castleman's disease (MCD) successfully treated with an anti-interleukin-6 receptor antibody (tocilizumab). This mesangial proliferative glomerulonephritis with interstitial nephritis was resistant to methylprednisolone treatment; however, it was markedly improved with tocilizu...

OBJECTIVE To investigate antibodies to complement 1q (anti-C1q) and investigate the correlation between anti-C1q titres and renal disease in systemic lupus erythematosus (SLE). METHODS 151 SLE patients were studied. In patients with biopsy proven lupus nephritis (n = 77), activity of renal disease was categorised according to the BILAG renal score. Sera were tested for anti-C1q by enzyme immu...

The deposition of anti-dsDNA antibodies in the glomerulus is believed to play a critical role in the pathogenesis of nephritis in SLE. However, an absolute correlation between serum levels of anti-dsDNA antibodies and renal disease has not been found. Recently a glomerular binding assay (GBA) has been developed to detect IgG binding to isolated rat glomeruli. We have used the GBA to study sera ...

Although the study of experimental nephritis by physiological methods shows that the most striking effect of cantharidin is injury of the blood vessels, the great abundance of mitotic figures in the tubular epithelium in the stage of repair points to an equally widespread and severe epithelial injury. Caution must therefore be observed in ascribing the physiological disturbances of kidney funct...

Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in the interstitial infiltrate, indicating a cellular autoimmune response. After immunosuppressive treatmen...

This study was carried out to determine the prevalence and type of renal lesions in cattle that were slaughtered at the Ghaem (Shahriar) and Ziaran (Ghazvin) abattoirs. A total number of 405 clinically normal cattle were randomly selected and renal samples were taken for histopathological study. The cattle were divided into two groups according to sex, and female groups were divided into two ag...

Objective To assess the long-term outcome of lupus nephritis in children with systemic lupus erythematosus followed up over 12 years at a tertiary care teaching hospital in Eastern India. Material and Methods This is a retrospective observational study of the clinicopathological presentation, management, and outcome in 46 children with lupus nephritis over a period of 12 years at a tertiary t...