PURPOSE A phase I trial of intrathecal Spartaject Busulfan (SuperGen, Inc., San Ramon, CA) was conducted in children with neoplastic meningitis following recurrent primary brain tumors to describe toxicities, estimate the maximum tolerated dose (MTD), and document evidence of responses to this agent. EXPERIMENTAL DESIGN The continuous reassessment method was used to assign cohorts of patients...

background: viruses are by far the most common cause of meningitis in children. objectives: the aim of this study is to describe the epidemiology of viral/aseptic meningitis (am) in children (2 months - 15 years) in shiraz. materials and methods: this is a cross-sectional prospective-descriptive study from may 2001 to may 2002 in nemazi and dastgheib hospitals, shiraz. ev meningitis was diagnos...

despite recent innovations in the laboratory diagnosis of bacterial from nonbacterial meningitis, solid data-necessary for early determination of bacterial meningitis (bm) before organism growth in the culture medium-are missing. therefore cerebrospinal fluid (csf) lactate levels were evaluated as a possible means of differentiating the two clinical entities. this was a retrospective study. pat...

The small GTP-binding protein Rho and its target Rho-associated kinase trigger an intracellular signaling cascade that controls actin cytoskeleton and plays an essential role in cell motility and adhesion. A specific Rho-associated kinase inhibitor, Y-27632, has been reported to inhibit cancer invasion. Clinically, disseminated tumor cells in the cerebrospinal fluid invade the intraparenchymal ...

Objective: Meningitis is life-threatening condition and examination of the Cerebrospinal fluid (CSF) may not give a precise diagnosis and prognosis of different types of meningitis. Bacterial meningitis is still a very common problem especially in many developing countries. The aims of study are to estimate the importance and significance of Lactate Dehydrogenase (LDH), protein...

Background: Meningitis is a major cause of morbidity in the world. Previous studies showed that weather factors influence occurrence meningitis. A multiple linear regression model was developed to forecast meningitis cases Burkina Faso using factors. However, multivariate based on times series data may produce fallacious results given autocorrelation errors.

bacterial meningitis is still the leading cause of high morbidity and mortality among the children. the present study was conducted to determine the epidemiology, clinical characteristics of bacterial meningitis and to evaluate the risk factors associated with developing the infection.this cross sectional study was conducted in three hospitals of gaza strip -palestine during the period 2009. al...

background meningitis is an inflammation of the membranes, which surround the brain and spinal cord. early treatment of bacterial meningitis can prevent serious complications. in the last two decades, three vaccines have been developed against the three main bacterial species implicated in meningitis of children in western countries and vaccine-preventable invasive bacterial meningitis has decr...