OBJECTIVE To evaluate tumor responses to neoadjuvant therapy, according to the histopathological findings of surgical specimens of patients operated and treated for squamous cell carcinoma of the middle third and distal esophagus. METHODS We conducted a retrospective nonrandomized study including 97 patients distributed as follows: Group I - 81 (83.5%) underwent neoadjuvant radiation therapy,...

OBJECTIVE We analyzed the effect of neoadjuvant chemo radiation on feasibility and outcomes in rectal cancer patients undergoing laparoscopic resection of the rectum. METHODS This was a retrospective analysis of a consecutive series of laparoscopic resections for rectal cancer from 1998 to 2004 (N=60). RESULTS Eight patients received preoperative chemoradiation therapy (neoadjuvant group) f...

AIM To compare neoadjuvant chemoradiotherapy and surgery with surgery alone for resectable esophageal carcinoma. METHODS We used MEDLINE and EMBASE databases to identify eligible studies and manual searches were done to ensure no studies were missed. Trial validity assessment was performed and a trial quality score was assigned. RESULTS Eleven randomized controlled trials (RCTs) including 1...

Chemotherapy and hormonal treatment decisions for breast cancer are influenced by the expression of tumor biomarkers, including estrogen receptor, progesterone receptor and human epidermal growth hormone receptor 2 (HER2/neu). These biomarkers are most commonly assessed by immunohistochemical staining and fluorescence in situ hybridization studies performed on breast cancer biopsy specimens. Bi...

The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated. The present study consists of 24 patients with cervical cancer, including 12 patients in stages IB-IIIB with first-line surgical treatment and 12 patients in stages IIB-IIIB, with neoadjuvant thera...

BACKGROUND The use of neoadjuvant therapy before surgery for gastrointestinal cancer is increasing; however, patients may not complete both treatment components. Understanding completion rates of each treatment stage is necessary for treatment evaluation and to inform decision-making. This study evaluates reporting for recent neoadjuvant surgical trials, focusing on treatment progression and ot...

There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40-60% of rectal cancer patients treated with neoadjuvant chemoradiation achieve some degree of pathologic response. However, there is no effective method of predicting whic...

Adjuvant systemic chemotherapy has been shown to prolong survival in all subsets of patients with breast cancer. In addition, among patients with locally advanced breast cancer, neoadjuvant orpreoperative chemotherapy has improved the ability to perform breast-conserving therapy. This observation, combined with multiple preclinical hypotheses and the results of laboratory studies, has prompted ...

Abstract This study aimed to analyze the management of hemotherapy services (HS) in context COVID-19 pandemic from perspective municipal managers different regions Brazil. A qualitative approach with semi-structured interviews was applied HS three Brazilian capitals, Brazil, during period between September 2021 and April 2022. The textual content submitted lexicographic analysis using free acce...