Discussion |Threemuscles, thecircularorbicularis oris, depressor labii inferioris, andmentalis align the labiomental fold or cross it as they pass to their insertion.2 The fibers of the 3 muscles are attached to the skin by thick bands of fibroelastic fibers. Thementalismuscles originate from themandible and serve as paired elevators of the central lower lip.3 They usually overlap and insert in...

Necrobiosis lipoidica (NL) is a cutaneous disease entity that typically manifests as atrophic yellow plaques with telangiectasias on the anterior tibial region. Although NL is commonly associated with diabetes mellitus, the role of trauma in disease development is less commonly emphasized. The relationship between NL and the Köbner phenomenon has been established, as a few cases of NL occurring...

Necrobiosis lipoidica is a rare chronic granulomatous disease, often associated with diabetes mellitus. It due to collagen degeneration risk of ulceration. affects 0.3 1.2% diabetic patients, mainly in the leg. Its etiology not yet well understood. The diagnosis usually made clinically but skin biopsy may be necessary case atypical lesions. evolution ulceration and into squamous cell carcinoma ...

Discussion |Threemuscles, thecircularorbicularis oris, depressor labii inferioris, andmentalis align the labiomental fold or cross it as they pass to their insertion.2 The fibers of the 3 muscles are attached to the skin by thick bands of fibroelastic fibers. Thementalismuscles originate from themandible and serve as paired elevators of the central lower lip.3 They usually overlap and insert in...

We present a case of necrobiosis lipoidica (NL) with atypical early lesions and good response to topical tacrolimus. NL is a disease with clinical features that are seldom misinterpreted. Often histology just confirms the clinician's diagnosis. Only in rare cases, the clinical presentation and the involved body sites may be misleading. A 67-year-old diabetic woman was admitted to our department...

Necrobiosis lipoidica (NL) is a rare inflammatory granulomatous skin disorder closely associated with diabetes mellitus. The aim of this paper is to review and discuss all the treatment modalities proposed and tested for this disease. A systematic review of the existing literature was conducted to investigate all the available data and summarize all the clinical trials, case reports and origina...

 Dermatological problems occur with increased frequency in individuals with diabetes mellitus (DM). Cutaneous manifestations may be the first presenting sign of DM or even precede the diagnosis by many years. The main changes in the skin are due to alterations of microcirculation, the nervous system, and collagen. The most common skin problems in DM are acanthosis nigricans, necrobiosis l...