Necrobiosis lipoidica (NL) is a chronic granulomatous disease of the skin. A growing body literature suggest that janus kinase (JAK) inhibitors for may be effective in treatment skin diseases, including NL. Prior translational research identified activation JAK-STAT pathways by interferon gamma (IFNγ) and other cytokines integral to macrophage these diseases. We aimed evaluate safety efficacy t...

This will be an overview of our studies on biofilms and the diseases with which they are associated. Where possible, it include microbes that create these biofilms, their locations in body, impact innate adaptive immune systems. It all we have recently classified as eczema addition to those previously considered such. also psoriasis, tinea versicolor, leprosy, tertiary Lyme disease Alzheimer’s ...

AEGCG: annular elastolytic giant cell granuloma INTRODUCTION Annular elastolytic giant cell granuloma (AEGCG) is an uncommon condition belonging to the family of elastolytic granuloma, which also includes actinic granuloma, atypical necrobiosis lipoidica of the face and scalp, and Miescher’s granuloma. Classification of AEGCG as a distinct entity has been controversial. Although some consider i...

BACKGROUND Necrobiosis lipoidica diabeticorum (NLD) is a rare, granulomatous inflammatory skin disease of unknown origin, sometimes associated with diabetes mellitus. Skin lesions usually develop on the lower extremities and can progress toward ulceration and scarring. Many treatments have been proposed, but few have demonstrated consistent efficacy, and no standard regimens have emerged to dat...