The beneficial effects of beta blockers in younger patients with heart failure (HF) due to systolic dysfunction are well established. However, data from patients > or =70 years old with diabetes mellitus and HF are lacking. The Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors with heart failure [SENIORS] tested the efficacy of the vasodilator beta blocker ...

BACKGROUND It has been suggested that the antihypertensive agent nebivolol, a beta1-adrenoceptor-blocking agent that modulates the endogenous production of nitric oxide, is preferable to 'conventional' beta1-blockers in hypertensive patients with airway dysfunction. OBJECTIVES Since beta1-blockade by nebivolol is larger after repeated dosing than after a single oral intake, we have explored i...

A simple high-performance liquid chromatography RP-HPLC and two reproducible ultraviolet spectrophotometric methods were developed and validated for the estimation of nebivolol HCl and valsartan simultaneously in combined pharmaceutical solid dosage form. The wavelength fixed for spectrophotometric measurement of valsartan at 246.6 nm, nebivolol HCl at 280.2 nm for the simultaneous equation and...

We aimed to investigate the effects of nebivolol and quinapril treatments on P-wave duration and dispersion in hypertensive patients. Hypertensive patients who were in sinus rhythm were assigned to the two treatment groups and received either 20 mg quinapril/day or 5 mg nebivolol/day. P-Wave dispersion (PWD) was measured at baseline and after four weeks of treatment and defined as the differenc...

AIMS Exposure to high altitude (HA) hypoxia decreases exercise performance in healthy subjects. Although β-blockers are known to affect exercise capacity in normoxia, no data are available comparing selective and nonselective β-adrenergic blockade on exercise performance in healthy subjects acutely exposed to HA hypoxia. We compared the impact of nebivolol and carvedilol on exercise capacity in...

Abstract Background Central blood pressure and central pulse have a better correlation with the risk of cardiovascular disease compared to those peripheral measurement. In previous study, second-generation beta-blocker showed poor CBP-lowering effects. However, effect on CBP by third-generation beta-blockers is not fully elucidated. Thus, this randomised study investigated whether nebivolol-bas...

de Boer, R., Doehner, W., van der Horst, I., Anker, S., Babalis, D., Roughton, M., Coats, A., Flather, M., van Veldhuisen, D. (2010). Influence of Diabetes Mellitus and Hyperglycemia on Prognosis in Patients >70 Years Old With Heart Failure and Effects of Nebivolol (Data from the Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure [SENIORS]...

Nebivolol, β1 selective drug is a third generation β blocker with nitric oxide donating antiproliferative and antioxidant properties which are useful to maintain a proper metabolic profile compared to atenolol, a β1 selective drug most commonly used. A prospective randomized parallel double blind study was conducted in patients with essential hypertension. Group A received nebivolol and group B...

AIM It has previously been shown that β-blocker therapy reduces QT dynamics in heart failure patients. The aim of this study was to demonstrate this improvement with the third-generation β-blocker, nebivolol. METHODS A total of 72 heart failure patients with systolic dysfunction were included in the study. Corrected QT (QTc) and QT dispersion (QTcd) were measured manually by two independent o...

AIM To study the effect of nebivolol on liver fibrosis induced by common bile duct ligation (BDL) in rats. MATERIALS AND METHODS After BDL, Wistar rats were divided into three groups (n=24): SO, sham-operated animals; BDL, BDL rats without treatment; BDL+N, BDL rats treated with nebivolol for five weeks. Alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, total bi...