The mnd mouse, a model of neuronal ceroid lipofusinosis (NCL), has a profound vitamin E deficiency in sera and brain, associated with cerebral deterioration characteristic of NCL. In this study, the vitamin E deficiency is corrected using dietary supplementation. However, the histopathological features associated with NCL remained. With use of a bioinformatics approach based on high-resolution ...

– The purpose of this paper is to explore the following issues in depth: is Non-Classical Logic, by any means, useful to Mathematics at all? Do we see any use in any Non-Classical Logic system in the scope of Mathematics? Can one confound Mathematics with, for instance, Fuzzy Logic applications? If NCL is not useful in Mathematics, is it useful, for instance, in Theology at all? Where lies the ...

A throughput estimation formula for optimally pipelining NULL Convention Logic (NCL) asynchronous circuits was presented in the literature. However, it ignores register delays. This paper presents a precise throughput derivation formula for pipelined NCL circuits. The formula was verified by Spice simulation and can be used for static timing analysis.

Congenital neuronal ceroid-lipofuscinosis (NCL) is a devastating inherited neurodegenerative disorder of unknown metabolic basis. Eight patients with this rare disorder, all with similar clinical and neuropathological findings, have been reported, and here we describe two further patients. Previously, we showed that a mutation in the cathepsin D gene causes congenital NCL in sheep. On the basis...

Peptide-mercaptopropionylcysteine (MPA-Cys) thioesters show a surprisingly high reactivity in native chemical ligation (NCL) and allow thiol-additive free reactions. This facilitates sequential NCL reactions and ligation-desulfurization reactions in one-pot formats. The synthetic utility is demonstrated by the synthesis of a SH3 domain.

The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative diseases characterised by the accumulation of autofluorescent lipopigment in a variety of tissues. At least six different forms of NCL occur in humans and the disease has been identified in various animal species, including sheep. Clinical features of NCL are dementia, loss of vision, motor disturbances, and pr...

Neurons in the avian nidopallium caudolaterale (NCL), an endbrain structure that originated independently from the mammalian neocortex, process visual numerosities. To clarify the code for number in this anatomically distinct endbrain area in birds, neuronal responses to a broad range of numerosities were analyzed. We recorded single-neuron activity from the NCL of crows performing a delayed ma...

Post-assembly functionalization of supramolecular nanostructures has the potential to expand the range of their applications. We report here the use of the chemoselective native chemical ligation (NCL) reaction to functionalize self-assembled peptide amphiphile (PA) nanofibers. This strategy can be used to incorporate specific bioactivity on the nanofibers, and as a model, we demonstrate functi...