PURPOSE Chemokine receptors are implicated in metastasis of several malignant tumors. This study was done to evaluate the contribution of chemokine receptors CXCR4 and CCR7 to metastasis of human nasopharyngeal carcinoma. EXPERIMENTAL DESIGN Reverse transcription-PCR, immunohistochemistry, and flow cytometry were used to evaluate mRNA and protein expression of CXCR4 and CCR7 in nasopharyngeal...

OBJECTIVES An independent and updated historical cohort mortality study was conducted among chemical plant workers to investigate further an association between exposures to formaldehyde and particulates and cancers of the nasopharynx and lung reported in an earlier National Cancer Institute study of the same plant. METHODS Subjects were 7359 workers who were first employed between 1941 and 1...

synchronous cancer is referred to two or more histological distinct malignancies diagnosed during the same hospital admission. globally more than 1 million people get colorectal cancer yearly resulting in about 0.5 million deaths. vulvar cancer is the fourth most common gynecologic cancer (following the corpus uterine cancer, cancer of ovary and cervix) and comprises only 4 percent of malignanc...

PURPOSE To study the necessity of repeat computed tomography (CT) scan and replanning and know a more accurate time using weekly kilovoltage cone beam computed tomography (kV-CBCT) scans for patients with nasopharyngeal carcinoma (NPC) during radiotherapy. METHODS AND MATERIALS Thirteen NPC patients treated with IMRT were enrolled into this prospective study. Weekly pretreatment kV-CBCT scans...

OBJECTIVE To evaluate the long term outcome after endoscopic endonasal resection of juvenile nasopharyngeal angiofibromas (JNA). METHODS Retrospective study of a series of 21 consecutive patients undergoing endoscopic resection of JNA (type I - IIIa according to Fisch) at two Hospital Centers between 1993 and 2002. Mean follow-up was 51.7 months (range 5-120). Extension to the medial aspect o...

The Bmi-1 oncoprotein regulates proliferation and oncogenesis in human cells. Its overexpression leads to senescence bypass in human fibroblasts and immortalization of human mammary epithelial cells. In this study, we report that compared with normal nasopharyngeal epithelial cells (NPEC), Bmi-1 is overexpressed in nasopharyngeal carcinoma cell lines. Importantly, Bmi-1 was also found to be ove...

Mutation of the p53 gene is a common event in human cancer. Interestingly, p53 mutation is uncommon in nasopharyngeal carcinoma (NPC). The DeltaNp63 has been postulated to have a dominant-negative effect on the function of the p53 gene and may play a role in the pathogenesis of nasopharyngeal carcinoma. Immortalization is a common property of cancer cells and is believed to be an early event in...

background and aims. salivary glands are extremely susceptible to radiation injuries. the aim of this study was to evaluate radiation-induced xerostomia in patients with nasopharyngeal carcinomas, referring to tabriz imam khomeini hospital in 2005-2006. materials and methods. thirty patients with nasopharyngeal carcinomas, who received conventional radiotherapy, were included in the present stu...

Nasopharyngeal carcinoma is a metastatic malignant tumor originating from nasopharyngeal epithelium. Lacking or nonspecific symptoms of patients with early stage nasopharyngeal carcinoma have significantly reduced the accuracy of diagnosing and predicting nasopharyngeal carcinoma development. This study aimed to identify gene signatures of nasopharyngeal carcinoma and uncover potential mechanis...

BACKGROUND BRCC3 has been found to be aberrantly expressed in breast tumors and involved in DNA damage response. The contribution of BRCC3 to nasopharyngeal carcinoma prognosis and radiosensitivity is still unclear. METHODS Immunohistochemical analysis of BRCC3 was carried out in 100 nasopharyngeal carcinoma tissues, and the protein level was correlated to patient survival. BRCC3 expression o...