نتایج جستجو برای: narrow absorption window

تعداد نتایج: 246595  

Journal: :Science 2001
F Pouille M Scanziani

The temporal resolution of neuronal integration depends on the time window within which excitatory inputs summate to reach the threshold for spike generation. Here, we show that in rat hippocampal pyramidal cells this window is very narrow (less than 2 milliseconds). This narrowness results from the short delay with which disynaptic feed-forward inhibition follows monosynaptic excitation. Simul...

1994
ANDREW CHOI

Many existing fundamental frequency recognition (FFR) algorithms return reliable results when the analysis window is suuciently wide. In some applications, however, the response time, i.e., the sum of the width of the analysis window and the computation time for the FFR algorithm, must be made as short as possible. This paper studies the eeect of window width on the accuracy of two FFR algorith...

2015
I. S Sengupta SH Shah N. Shah

The oral delivery of drugs with a narrow absorption window in the gastrointestinal tract (GIT) is often limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the site of absorption. In-situ gel provides the best way to overcome problems of immediate release and short gastrointestinal residence of liquids. The in situ gel dosage...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Ritu Lal Juthamas Sukbuntherng Ezra H L Tai Shubhra Upadhyay Fenmei Yao Mark S Warren Wendy Luo Lin Bu Son Nguyen Jeanelle Zamora Ge Peng Tracy Dias Ying Bao Maria Ludwikow Thu Phan Randall A Scheuerman Hui Yan Mark Gao Quincey Q Wu Thamil Annamalai Stephen P Raillard Kerry Koller Mark A Gallop Kenneth C Cundy

Baclofen is a racemic GABA(B) receptor agonist that has a number of significant pharmacokinetic limitations, including a narrow window of absorption in the upper small intestine and rapid clearance from the blood. Arbaclofen placarbil is a novel transported prodrug of the pharmacologically active R-isomer of baclofen designed to be absorbed throughout the intestine by both passive and active me...

2012
Amit Patel

Oral gastroretentative dosage forms offer many advantages for drugs having absorption from upper gastrointestinal tract and improve the bioavailability of medication that is characterized by narrow absorption window. The purpose of present study was to formulate and develop a new gastroretentative controlled release diffusion of furosemide from the cellulose acetate floating microspheres. Furos...

2016
Parveen Kumar Sharma Gyati Shilakari Asthana Abhay Asthana

Site specific drug delivery has become the important aspect of research. In present study focused has been made to formulate gastroretentive drug delivery (GRDDS) of drugs having narrow absorption window or having good absorption at proximal part of gastrointestinal tract (GIT) to deliver at stomach site. Hydrogel based gastroretentive formulation of ramipril were prepared by gas blowing techni...

2015
Shu-Ju Tsai Mihaela Ballarotto Hung-Chih Kan Raymond J. Phaneuf

We report on the effects of enhanced absorption/scattering from arrays of Au nanopillars of varied size and spacing on the spectral response of a P3HT:PCBM bulk heterojunction solar cell. Nanopillar array-patterned devices do show increased optical extinction within a narrow range of wavelengths compared to control samples without such arrays. The measured external quantum efficiency and calcul...

Journal: :Current opinion in neurobiology 2005
Aihua Fu Weiwei Gu Carolyn Larabell A Paul Alivisatos

Conventional organic fluorophores suffer from poor photo stability, narrow absorption spectra and broad emission spectra. Semiconductor nanocrystals, however, are highly photo-stable with broad absorption spectra and narrow size-tunable emission spectra. Recent advances in the synthesis of these materials have resulted in the generation of bright, sensitive, extremely photo-stable and biocompat...

Journal: :Medical engineering & physics 2000
B Y Lu R S Yang W L Lin K S Cheng C Y Wang T S Kuo

This study investigates the optimal external parameters for using an ultrasound applicator for treating bone tumors. This system utilized spherically arranged applicators such as scanned focused ultrasound, and spherically focused multielement applicators. The power deposition pattern is modeled as geometric gain with exponential attenuation. The specific absorption rate ratio (SARR) criteria h...

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