Synthesis of compound libraries and their concurrent assessment as selective reagents for probing and modulating biological function continues to be an active area of chemical biology. Microwave-assisted solid-phase Dötz benzannulation reactions have been used to inexpensively synthesize 2, 3-disubstituted-1, 4-naphthoquinone derivatives. Herein, we report the biological testing of a small libr...

Four different methods were evaluated for the determination of the creatinine content of a seriesof 24-hour urine samples. The results indicate that the methods of Folin, Hare, and Van Pilsum give essentially the same values. The precision of the method of Sullivan and Irreverre was extremely poor and the values obtained were 2-8 times higher than those obtained by the other technics. The compo...

Picrorhiza kurroa is a well-known herb in Ayurvedic medicine. Although it shows antioxidant, antiinflammatory and immunomodulatory activities, it is most valued for its hepatoprotective effect. The rhizomes are widely used against indigestion problems since ancient times due to improper digestive secretions. Aim of this study was to explore antioxidant study of P. kurroa leaves for a new source...

Quinones such as 1,4-naphthoquinones are abundant in nature and naphthoquinone based natural products are known to possess anticancer activity. This pharmacophore is known to convey anticancer activity to some drugs such as streptonigrin, mitomycin A, etc. We synthesized and characterized different classes of naphthoquinone derivatives including bis naphthoquinone, 2-arylaminonaphthoquinone, be...

The reaction of naphthoquinone-oximes (3) and (4) with diazomethane yields directly, in one step, the oxazoles (5) and (6), respectively.

Naphthoquinones have been reported to be toxic to liver cells in vitro. Protein modification is associated with naphthoquinone-induced cytotoxicity. In addition, 1,2-naphthoquinone was found to bind covalently to cysteine residues of proteins of lung Clara cells incubated with naphthalene. To further identify the target proteins of the naphthoquinone, we raised polyclonal antibodies by immunizi...

3 The abbreviations used are: ROS, reactive oxygen species; VSMC, vascular smooth muscle cells, HA, hyaluronic acid; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; Has2, hyaluronan synthase 2; Hyal3, hyaluronidase 3; LMW-HA, low-molecular-weight HA; HMW-HA, highmolecular-weight HA; DPI, diphenyleneiodonium chloride; DMNQ, 2,3-Dimethoxy-1,4-naphthoquinone; GKT136901 (2-(2-chl...

Labeled avidin-biotin (LAB) enzyme-linked immunosorbent assay (ELISA) was applied to detect Japanese encephalitis OE) antibody in swine sera. Purified laGAr-01 vaccine of lE, biotin labeled anti-swine Ig or IgM rabbit IgG conjugate and horseradish peroxidase (HRP) were employed in the assay. The f1 chain specific anti-IgM conjugate could detect only IgM antibody, but the anti-Ig conjugate could...

Carbon-based solid acids (CSA) have grown in popularity recent years owing to their strong catalytic activity, thermal stability, and reusability. The size effect has a significant influence on the activity of carbon-based heterogeneous catalysts. impacts raw material shape, sulfonation degree, produced were examined this article. Various sizes microcrystalline cellulose (MCC), nanocrystals (CN...