نتایج جستجو برای: nanoconjugate
تعداد نتایج: 106 فیلتر نتایج به سال:
BACKGROUND Carbon nanotubes (CNTs) have unique physical and chemical properties. Furthermore, novel properties can be developed by attachment or encapsulation of functional groups. These unique properties facilitate the use of CNTs in drug delivery. We developed a new nanomedicine consisting of a nanocarrier, cell-targeting molecule, and chemotherapeutic drug and assessed its efficacy in vitro....
Nitric oxide is a cell signaling molecule that can be a potent inducer of cell death in cancers at elevated concentrations. Nitric oxide molecules are short-lived in vivo; therefore, NO-donating prodrugs have been developed that can deliver NO to tissues at micromolar concentrations. However, NO is also toxic to normal tissues and chronic exposure at low levels can induce tumor growth. We have ...
Liquid-phase transmission electron microscopy (TEM) can probe and visualize dynamic events with structural or functional details at the nanoscale in a liquid medium. Earlier efforts have focused on the growth and transformation kinetics of hard material systems, relying on their stability under electron beam. Our recently developed graphene liquid cell technique pushed the spatial resolution of...
Metastases are responsible for 90% of human cancer deaths. Most solid tumors metastasize through the circulation system, and the sentinel lymph node (LN) is typically the first site reached by the disseminating malignant cancer cells. The detection of LN metastases is therefore crucial for accurate tumor staging and therapeutic decision making. The current standard method for LN assessment is l...
Multifunctional nanoparticles (MNPs) that combine unique superparamagnetic properties and fluorescence emission are promising bimodal tracers for the noninvasive diagnosis of malignant cells both in vitro and in vivo. The selective recognition of specific cancer cells impacts diagnostic sensitivity, and it can be accomplished by the functionalization of MNPs with molecules that have a high affi...
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