Naltrexone/bupropion extended release (NB) is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of ≥30 or ≥27 kg m(-2) and ≥1 weight-related comorbidity (e.g. hypertension, type 2 diabetes and dyslipidaemia). In phase 3 clinical studies, nausea occurred in significantly higher proportions of ...

In this paper, we compare the efficiency of two models to estimate the surface displacements due to continental water storage (CWS) variations over continental North America. The first model, the monthly North America Land Data Assimilation System Phase 2 Noah (NLDAS2 Noah) is a model of CWS restricted to North America. The second data set, the Global Land Data Assimilation System Noah (GLDAS N...

ackground: The presence of a comorbid tic disorder may predict a poorer outcome in the acute treatment of pediatric bsessive-compulsive disorder (OCD). ethods: Using data from the National Institute of Mental Health (NIMH)-funded Pediatric OCD Treatment Study (POTS) that ompared cognitive-behavior therapy (CBT), medical management with sertraline (SER), and the combination of CBT and ER (COMB),...

The toxicity of synergism of and resistance to insecticides in four strains of German cockroach, Blattella germanica (L.), were investigated. Toxicity of nine insecticides by topical application to the susceptible strain varied greater than 2,000-fold, with deltamethrin (LD50 = 0.004 micrograms per cockroach) and malathion (LD50 = 8.4 micrograms per cockroach) being the most and least toxic, re...

OBJECTIVES To compare the efficacy of fesoterodine 4 mg versus 8 mg in treating subjects with overactive bladder (OAB) syndrome. METHODS This is a pooled analysis of data from 2 randomized placebo (PBO)-controlled phase III trials. Eligible subjects with frequency and urgency or urgency urinary incontinence (UUI) were randomized to PBO or fesoterodine 4 or 8 mg for 12 weeks. Subjects assessed...

We have previously described a novel class of nonnucleoside reverse transcriptase (RT) inhibitors, the pyrrolobenzoxazepinone (PBO) and the pyridopyrrolooxazepinone (PPO) derivatives, which were effective inhibitors of human immunodeficiency virus type 1 (HIV-1) RT, either wild type or carrying known drug resistance mutations (G. Campiani et al., J. Med. Chem. 42:4462-4470, 1999). The lead comp...

Global economy is undergoing a recession phase that had made competition tougher and imposed new business framework. Businesses have to shift from the classical management approaches to an Intelligent Project Based Organization Model (IPBOM) that provides flexibility and agility. IPBOM is intended to reinforce the proven advantages of Project Based Organization (PBO) by the use of suitable Ente...

RATIONALE Eslicarbazepine acetate (ESL) is a once-daily oral antiepileptic drug for the treatment of partial-onset seizures. Adverse events such as dizziness and somnolence reported in clinical studies suggest that ESL has detectable central nervous system (CNS) effects in addition to its antiepileptic effects. This Phase I study evaluated the abuse liability of ESL compared with that of alpraz...

background : insecticide resistance is one of the serious problems for german cockroach control program. this study was conducted to determine the bendiocarb and carbaryl resistance mechanisms in german cockroaches using the piperonyl butoxide (pbo). methods : bioassay tests were conducted with 4 to 6 different concentrations of both insecticides with four replicates of 10 susceptible strain co...