نتایج جستجو برای: nano drug carriers
تعداد نتایج: 675806 فیلتر نتایج به سال:
As nano-scale drug delivery systems, smart micelles that are sensitive to specific biological environment and allowed for target site-triggered drug release by reversible stabilization of micelle structure are attractive. In this work, a biocompatible and pH-sensitive copolymer is synthesized through bridging poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC) block and poly (D, L-lactide) (...
As the most common cause of dementia among the elderly results in cognitive and ‎behavioral impairment, Alzheimer’s disease (AD) is characterized with aggregation of senile ‎plaques (Beta-amyloid protein), cortical atrophy and ventricular enlargement. Unfortunately, ‎conventional methods like acetyl cholinesterase inhibitor drugs, are not so effective owing to ‎restrictive...
BACKGROUND Drug delivery in polymeric micelles combined with tumor irradiation by ultrasound results in effective drug targeting, but this technique requires prior tumor imaging. A technology that combined ultrasound imaging with ultrasound-mediated nanoparticle-based targeted chemotherapy could therefore have important applications in cancer treatment. METHODS Mixtures of drug-loaded polymer...
Hierarchical structured nanomaterials with diverse functionality, such as magnetic susceptibility, stimuli-responsiveness, environmental sensing and biocompatibility, are highly sought after for biomedicine and biodetection alike. In this study, we designed and fabricated a new kind of multifunctional core/shell nanospheres as biodegradable targeted drug carriers, the controlled drug release pr...
Background: In recent years, nanotechnology with modern advances in the macromolecular design of nano-carriers has proved to be helpful in the development of drugs delivery systems. This research represents a novel co-administration of nano-vehicles, known as liposomes. Liposomes efficiently encapsulate curcumin and bromocriptine (BR) in a polymer structure, which results in enhanced aqueous so...
tilmicosin (tlm) is an important antibiotic in veterinary medicine with low bioavailability and safety. this study aimed to formulate and evaluate physicochemical properties, storage stability after lyophilization and antibacterial activity of three tlm-loaded lipid nanoparticles (tlm-lnps) including solid lipid nanoparticles (slns), nanostructured lipid carriers (nlcs) and lipid-core nanocapsu...
Background Nanotechnology-based drug delivery systems exhibit promising therapeutic efficacy in cancer chemotherapy. However, ideal nano drug carriers are supposed to be sufficiently internalized into cancer cells and then release therapeutic cargoes in response to certain intracellular stimuli, which has never been an easy task to achieve. Objective This study is to design mesoporous silica ...
Pancreatic stellate cells (PSCs) play a key role in desmoplastic stroma, which is characteristic of pancreatic ductal adenocarcinoma (PDAC), and they also enhance the malignancy cancer cells. Our previous study reported chloroquine's mitigating effects on PSC activation; however, drug known to induce adverse clinical practice. The present aimed reduce chloroquine doses develop useful pre‑treatm...
Development of targeted nanoparticle drug carriers often requires complex synthetic schemes involving both supramolecular self-assembly and chemical modification. These processes are generally difficult to predict, execute, and control. We describe herein a targeted drug delivery system that is accurately and quantitatively predicted to self-assemble into nanoparticles based on the molecular st...
In the present study, functionalized bioresorbable nanomaterials (less than 50 nm in size) were formulated to specifically attach to cancerous (not healthy) bone to form an implant used to treat bone cancer. After attachment, sustained release of anti-cancer agents occurred at targeted sites. Specifically, inorganic biodegradable nanomaterials (including ceramics like hydroxyapatite or HA) were...
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