Curcumin was converted into its oligosaccharides by cultured Parthenocissus tricuspidata cells-catalyzed glycosylation. In addition to curcumin 4'-O-glucoside (9%) and curcumin 4',4''-O-diglucoside (14%), two curcumin oligosaccharides, i.e., curcumin 4'-O-gentiobioside (16%) and curcumin 4'-O-gentiobiosyl-4''-O-glucoside (3%), were isolated from P. tricuspidata cells treated with curcumin. ____...

Islet transplantation is one of many therapeutic approaches for the treatment of diabetes. During transplant procedures, the isolated islets are subjected to hypoxic conditions, and undergo the apoptotic process. Curcumin has a cytoprotective effect, and may therefore be useful for the protection of islets under hypoxia. However, curcumin is hydrophobic, and an efficient curcumin carrier is req...

PURPOSE Telomerase is expressed in most cancers, including breast cancer. Curcumin, a polyphenolic compound that obtained from the herb of Curcuma longa, has many anticancer effects. But, its effect is low due to poor water solubility. In order to improve its solubility and drug delivery, we have utilized a β-cyclodextrin-curcumin inclusion complex. METHODS To evaluate cytotoxic effects of cy...

Various ratios PEOz-PDLLA diblock copolymers were synthesized through ring-opening polymerization of DL-lactide initiated by monohydroxyl terminated poly(2-ethyl-2-oxazoline) (PEOz-OH). The chemical composition and molar mass the resulting determined using NMR GPC. Spherical micelles with a diameter from 104 to 136 nm obtained via self-assembly in water, as evidenced TEM DLS. CMC was well below...

Objective: The objective of this study was to formulate and evaluate the Curcumin (CUR) encapsulated sodium alginate (SA)/badam gum (BG)/kaolin (KA) microbeads for controlled drug release studies.
 Methods: fabricated were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD), ele...

objective: adipocyte and skeletal muscle are important tissues which contribute the development and progression of metabolic disorder. insulin has a major regulatory function on glucose metabolism in these tissues by redistributing glucose transporter (glut4) from intracellular vesicles to the cell surface. today, due to the side effects of chemical medications attendance to herbal medicines is...

objective: curcumin is a major constituent of turmeric and influences many functions of the brain. in the present study, we investigated the effect of curcumin on yawning induced by apomorphine in rats. materials and methods: curcumin administered orallyfor 10 consecutive days. yawning was induced by subcutaneous (s.c.) injection of apomorphine (a dopamine receptor agonist) and the number of ya...

Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent. The systemic bioavailability of curcumin is low, perhaps attributable, at least in part, to metabolism. Indirect evidence suggests that curcumin is metabolized in the intestinal tract. To investigate this notion fu...