PURPOSE This study proposes an alternative preparation method of platelet-rich plasma (PRP). Specifically, we compare the use of thrombin receptor agonist peptide-6 (TRAP) and bovine thrombin as a clotting agent in the preparation of PRP. MATERIALS AND METHODS PRP was prepared by centrifugation and clotted with thrombin or TRAP. In vitro clotting times were monitored as a function of TRAP con...

Early vascularization is a prerequisite for successful bone healing and endothelial progenitor cells (EPC), seeded on appropriate biomaterials, can improve vascularization. The type of biomaterial influences EPC function with bioglass evoking a vascularizing response. In this study the influence of a composite biomaterial based on polylactic acid (PLA) and either 20 or 40% bioglass, BG20 and BG...

The preparation of amorphous nanopowders by flame synthesis opens access to common soda-lime, metal-doped glasses or bioglasses in the range of 20-80 nm and offers an alternative to conventional wet-phase preparation, solid state reactions or melting.

Bioactive glasses synthesized by the sol-gel technique possess many of the qualities associated with an ideal scaffold material for a bone graft substitute. In view of the potential clinical applications, we performed a detailed in vitro study of the biological reactivity of synthesized 58S bioactive glass containing-zinc, in terms of osteoblast morphology, proliferation, and deposition of a mi...

The thermoluminescence technique was employed to study bioglass matrix prepared using the traditional of glass making. synthesized were investigated X-ray diffraction (XRD), and differential thermal analysis (DTA) has been studied. highest thermoluminescent intensity found for composition 26.91 % CaO, 45.68 SiO2, 2.50 P2O5, 25.094 %Na2O (mol%), with only one glow peak at 460 k. TL response illu...

Bone scaffolds are often fabricated by initially producing custom-made filaments twin-screw extruder and subsequently fabricating into 3D using fused deposition modelling. This study aims to directly compare the effect of two alternative silica-rich filler materials on thermo-mechanical properties such after extrusion printing. Poly (DL-lactide-co-glycolide) (PDLGA) was blended with either 45S5...

Biomaterial coatings on dental implants are increasingly being used as a solution to the problems of rejection and implant loss. Bioglass® has been seen promising material for coating metal implants, increasing integration rate improving bond between bone implant. Multifunctional bioactive glasses can exhibit antibacterial, antitumor antioxidant effects with addition therapeutic ions. The ceriu...