BACKGROUND While randomized controlled trials (RCTs) are based on strict inclusion/exclusion criteria, non-interventional studies (NISs) might provide additional information to guide management in patients more representative to the real-world setting. The aim of this study was to compare baseline characteristics of patients receiving intravitreal treatment in the NIS OCEAN with those from publ...

This is a retrospective, multicenter study of consecutive patients with nAMD scheduled for visit and/or treatment an intravitreal injection (IVI) during the 3 months before lockdown in Ophthalmology Departments six centers Europe.The was conducted on 546 patients, which 55.13% were females, almost 100% White/Caucasian race, and 71.53% presented type 1 macular neovascularization (NVM). A total 6...

We present the first unconstrained nonadiabatic molecular dynamics (NAMD) simulations of photocatalytic water oxidation by small hydrated TiO2 nanoparticles using Tully surface hopping and time-dependent density functional theory. The results indicate that ultrafast electron-proton transfer from physisorbed water to the photohole initiates the photo-oxidation on the S1 potential energy surface....

This tutorial explains how NAMD and related tools can be used to setup and perform alchemical freeenergy simulations within the free-energy perturbation (FEP) theory. The force-field independent, “zero-sum” transformation of ethane into ethane is used as an introductory, prototypical example. FEP is then used to compute the free energy of charging a naked Lennard-Jones particle into a sodium io...

PURPOSE To compare treatment patterns of intravitreal ranibizumab and aflibercept for the management of neovascular age-related macular degeneration (nAMD) in a real-world setting over the first 12 months of treatment. METHODS A proprietary clinical database was used to identify treatment-naïve patients with nAMD in the USA with claims for ranibizumab or aflibercept between November 1, 2011 a...

Anti-vascular endothelial growth factor (anti-VEGF) treatment is the gold standard of care for neovascular age-related macular degeneration (nAMD). To strike a balance between burden and vision improvement, treat-and-extend (T&E) regimen preferred approach to administer anti-VEGF treatment. To facilitate implementation T&E nAMD in Hong Kong, panel retinal experts, with support Bayer Healthcare,...