Background: The role of smoking and alcohol consumption in the pathogenesis of psoriasis is well-known; however, certain published studies have focused on the relationship between substance abuse and psoriasis. The present study was conducted to evaluate the prevalence of tobacco smoking, and substance and alcohol use in patients with psoriasis.Methods: Patients with a definite diagnosis ...

and poster production/management fees paid for by Astellas.P2631 Group for research and assessment of psoriasis and psoriatic arthriti-seinternational multi-center psoriasis and psoriatic arthritis reliabilitytrial (GRAPPA-IMPART): Assessment of psoriasis, nail lesions, peripheralarthritis, and dactylitis Alice Gottlieb, MD, PhD, Tufts-New England Medical Center, Boston, MA, Uni...

Currently, tumor necrosis factor alpha (TNF-alpha) inhibitors are widely used for many autoimmune disorders. However, they cause an immunocompromised status that sometimes leads to many cutaneous side effects including atypical infections. Herein, we report the first case of adalimumab-related Majocchi's granuloma.A 43-year-old Taiwanese male patient with chronic plaque-type psoriasis developed...

This study aims to investigate associations between observed clinical parameters and known genetic risk factors of psoriasis in a well-defined prospective cohort of paediatric patients with plaque psoriasis (n = 151). Significant associations were found for paediatric-onset psoriasis with ERAP1 (p = 0.002), IL23R (p = 0.01), LCE3C_LCE3B-del (p = 0.00049) and HLA-C*06 (p = 3.15 × 10(-30)). Psori...

BACKGROUND: The main vector of psoriasis therapy is suppression proliferative activity keratinocytes, normalization their differentiation, neutralization immune inflammation in the dermis and cytokine balance.
 AIM: study was to efficacy tolerability an IL-17A inhibitor (secukinumab) as monotherapy combination with methotrexate patients moderate severe vulgaris.
 MATERIALS AND METHODS...

Aims: psoriasis is a common immune related skin disorder which affects 2-3% of worldwide people. It has different types and involves most parts of skin, and nail. It also sometimes affects joints and internal organs. Few studies have been conducted on the characteristics of psoriasis in Iran. The purpose of this study was to determine the disease characteristics of psoriasis patients in the gen...