We have selectively inhibited Notch1 signaling in oligodendrocyte precursors (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of Notch1 in oligodendrocyte (OL) development and differentiation. Early development of OPCs appeared normal in the spinal cord. However, at embryonic day 17.5, premature OL differentiation was observed and ectopic immature OLs were present in ...

Asymmetric rotators with a 1,4-bis(ethynyl)bicyclo[2.2.2]octane (BCO) core are needed for engineering crystalline arrays of functional molecular rotors. Their synthesis uses carbinol, 2-methyl-3-butyn-2-ol, as a protecting group because of its polar character and its ability to sustain orthogonal functionalization with the further advantage of being readily removed. The synthesis in good yields...

Since the discovery in the early 1980s that 1-octen-3-ol, isolated from oxen breath, attracts tsetse fly, there has been growing interest in exploring the use of this semiochemical as a possible generic lure for trapping host-seeking mosquitoes. Intriguingly, traps baited with 1-octen-3-ol captured significantly more females of the malaria mosquito, Anopheles gambiae, and the yellow fever mosqu...

Two new beta-sitosterol esters have been isolated from the flowers of Punica granatum Linn. (Punicaceae) along with the known compounds n-tricosane (3), n-heptacosanyl n-hexanoate (4), olean-5,12-dien-3beta-ol-28-oic acid (5), and olean-12-en-3beta-ol-28-oic acid (6). The structures of the new phytosterols have been elucidated as stigmast-5-en-3beta-ol-3beta-dodecanoate (beta-sitosterol laurate...

Journal Subject Code: [Treatment:[23] Catheter-based coronary and valvular interventions:other Stanford Uni ni ive ve vers rs rsit it ity y y Sc Sc Scho ho h ol ol ol o o of f Me Me Medi di ici c c ne ne ne

The monohydroxy carotenoid from the moth Cerura vinula has been shown to be /?,/?-caroten-2-ol on the basis of electronic, infrared, proton magnetic-resonance, and mass spectra. On acid treat­ ment in the presence of molecular oxygen this carotenoid is dehydrogenated to 4',5-retro-ß,ßcaroten-2-one. The identification of /?„/?-caroten-2-ol by its retro product, its time course of acetylation, an...

We demonstrate that the motion of dark solitons (DSs) can be controlled by means of periodic potentials. The mechanism is realized in terms of cigar-shaped Bose-Einstein condensates confined in a harmonic magnetic potential, in the presence of an optical lattice (OL). In the case when the OL period is comparable to the width of the DS, we demonstrate that (a) a moving dark soliton can be captur...

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Online hemodiafiltration (OL-HDF), first described in 1985, is today a widely prescribed treatment modality for end-stage chronic kidney disease (CKD) patients. Other than in the United States, prescription of the treatment modality is widespread with a steady increase since its inception. Indeed, in Western Europe, more CKD patients receive OL-HDF than peritoneal dialysis, hitherto the second ...