N-Acetylcysteine (NAC) is the standard antidote treatment for preventing hepatotoxicity caused by acetaminophen (AAP) poisoning. This review summarizes recent evidence of AAP Several alternative intravenous regimens NAC have been suggested to improve patient safety reducing adverse drug reactions and medication errors. A two-bag infusion regimen (200 mg/kg over 4 h, followed 100 16 h) reported ...

Background: Diabetes mellitus is a systemic condition that affects various organs, including the eyes. N-acetylcysteine ​​(NAC) functions as an antioxidant because it belongs to thiol group synthesis glutathione. However, availability of cysteine ​​in body only 15%, so ​​supplementation can help with oxidative stress in diabetic cataracts. That will prevent reaction lipid peroxidase and formati...

OBJECTIVE To evaluate whether N-acetylcysteine (NAC) infusion during the first week of life reduces the risk of death or bronchopulmonary dysplasia (BPD) in infants with extremely low birth weight. Study design In a Nordic multicenter, double-blind trial, infants (n=391) weighing 500 to 999 g and on ventilator or nasal continuous positive airway pressure were randomized before the age of 36 hou...

The complex formation between Cd(II) ions and N-acetylcysteine (H(2)NAC) in aqueous solution was investigated using Cd K- and L(3)-edge X-ray absorption and (113)Cd NMR spectroscopic techniques. Two series of 0.1 M Cd(II) solutions with the total N-acetylcysteine concentration c(H2NAC) varied between 0.2-2 M were studied at pH 7.5 and 11.0, respectively. At pH = 11 a novel mononuclear [Cd(NAC)(...

Extracellular glutathione deficiency and exaggerated oxidative stress may contribute to the pathogenesis of fibrosing alveolitis (FA). High-dose N-acetylcysteine (NAC) supplementation partially reverses extracellular glutathione depletion and oxidative damage, but effects on intracellular glutathione are unknown. Intracellular total glutathione (GSHt) and activation of bronchoalveolar lavage ce...

Ionizing radiation is known to cause tissue damage in biological systems, mainly due to its ability to produce reactive oxygen species (ROS) in cells. Many thiol antioxidants have been used previously as radioprotectors, but their application has been limited by their toxicity. In this investigation, we have explored the possible radioprotective effects of a newly synthesized thiol antioxidant,...

Abstract Contrast Induced Nephropathy is the most severe side-effect arising after non-ionic iodinated contrast agents (CAs) intravenous administration. The use of antioxidants (i.e., N-Acetylcysteine; NAC) one attempted prevention approaches. Herein, we describe microfluidic-assisted synthesis polymeric nanoparticles (NPs) as new multifunctional blood pool CA. aim this research to co-encapsula...

BACKGROUND Acute kidney injury (AKI) following prolonged laparoscopy is a documented phenomenon. Carbon dioxide pneumoperitoneum induces oxidative stress. Previous experimental studies have shown that the antioxidant, N-acetylcysteine, protects the rat from AKI following ischemia-reperfusion. The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) on rat renal function after...

In the present study, we tested effect of small-molecular-weight redox molecules on collagen-induced platelet aggregation. We used N-acetylcysteine amide (AD4/NACA), form (NAC), a thiol antioxidant with improved lipophilicity and bioavailability compared to NAC, thioredoxin-mimetic (TXM) peptides, TXM-CB3, TXM-CB13, TXM-CB30. All compounds significantly inhibited aggregation induced by collagen...