PURPOSE EML4-ALK is a lung cancer oncogene, and ALK inhibitors show marked therapeutic efficacy for tumors harboring this fusion gene. It remains unsettled, however, how the fusion gene should be detected in specimens other than formalin-fixed, paraffin-embedded tissue. We here tested whether reverse transcription PCR (RT-PCR)-based detection of EML4-ALK is a sensitive and reliable approach. ...

In order to explore the heat storage properties of phase change paraffin, a calculation model for melting paraffin was established based on equivalent capacity method. A finite element software (COMSOL) used study influence different inclination angles paraffin. The results show that process is determined by conduction and natural convection transfer, transfer plays significant role in Phase ex...

In this work, a series of novel paraffin inhibitor, polyaminoamide (PAA), was designed and prepared by aminolysis and poly-condensation using soybean oil and canola oil as the raw material. The property of the PAAs as paraffin inhibitor was investigated, the results show several PAA samples are potent in paraffin inhibition, and PPC-2 is the most effective one. Besides, the paraffin crystal mor...

A challenge to the simulation of Fischer–Tropsch reaction system is lack reliable kinetic models which correctly account for deviations from ideal polymerisation behaviour. The current trend in literature attribute these effects only. This ignores that reactions synthesis contain many aspects an equilibrium-controlled process. arises since rate chain growth much faster than monomer formation CO...

BACKGROUND Following the discovery that mutant KRAS is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies, the tumours of patients with metastatic colorectal cancer are now profiled for seven KRAS mutations before receiving cetuximab or panitumumab. However, most patients with KRAS wild-type tumours still do not respond. We studied the effect of other downstre...