نتایج جستجو برای: n gene
تعداد نتایج: 2011456 فیلتر نتایج به سال:
Background and Objective: Endurance activity affects muscle gene expression leading to the improvement of its function and effectiveness. Meanwhile, PGC-1 alpha transcription factor increases mitochondrial biogenesis in skeletal muscles. This study was designed to investigate the effect of an endurance activity program on pgc-1 alpha expression gene of fast and slow twitch muscles. Materials...
Objective(s): Coronary artery disease (CAD) which may lead to myocardial infarction (MI) is a complex one. Great effort has been devoted to identification of genes that increase susceptibility to CAD or provide protection. A 21-bp deletion in the MEF2A gene, which encodes a member of the myocyte enhancer factor 2 family of transcription factors, has been reported in patients of a single pedigr...
Background and purpose: Gastric cancer has been considered as the second lethal cancer throughout the world and the incidence of this cancer in Ïran is 25 in 10000 people per year. Ïnterleukin-11 (ÏL-11), a member of ÏL-6 family, may play some role in developing gastric cancer via activation of the JÂK/STÂT signaling pathway. Ïn this study, the level of ÏL-11 gene expression was determined in g...
hereditary inclusion body myopathy (hibm) is an adult-onset hereditary myopathy, usually with distal onset and quadriceps sparing. this myopathy is autosomal recessive and associated to upd-n-acetylglucosamine-2-epimerase/n-acetylmannosamine kinase (gne) gene mutations. in this study, we report a novel gne homozygous point mutation c.1834t>g that results in amino acid substitution of cysteine 6...
materials and methods this definitive and cross-sectional study was conducted in tehran, iran. a total of 15 s. aureus isolates were collected from wound samples with sterile swabs and were identified by the conventional diagnostic tests. the antibiotic susceptibility pattern was performed according to the clinical and laboratory standards institute (clsi, 2012) protocol. the meca gene, staphyl...
Background. The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating and releasing some myokines. Nevertheless, the effectiveness of each training method in this regard is still not certain. Objective(s). This ...
Introduction: In high-fat diet-induced obesity, the levels of cathepsin L (CTSL) and cathepsin B (CTSB) increase in adipocytes, resulting in insulin resistance in the adipose tissue. In this study, the preventive effect of endurance training on the gene expression of CTSL and CTSB was investigated in the adipose tissue of mice with a high-fat diet. Materials and Methods: Twenty-one male mice (a...
Background: This study aimed to investigate the effect of eight weeks of interval training on gene expression of liver X receptors (LXR) in Wistar male rats. Materials and Methods: In this study, 24 male wistar rats (200-250 g) were randomly used to three groups for this purpose, 24 male Wistar rats were prepared and divided into three groups: control (8 = n), high intensity intermittent exerc...
Background: Splicing by overlap extension (SOE) PCR is used to create mutation in the coding sequence of an enzyme in order to study the role of specific residues in protein’s structure and function. Objectives: We introduced a nested-SOE-PCR (N –SOE-PCR) in order to increase the specificity and generating mutations in a gene by SOE-PCR. Materials and Methods: Genomic DNA from Bacillus thermo...
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