While many general features of cell fate specification in the sea urchin embryo are understood, specific factors associated with these events remain unidentified. SpOtx, an orthodenticle-related protein, has been implicated as a transcriptional activator of the aboral ectoderm-specific Spec2a gene. Here, we present evidence that SpOtx has the potential to alter cell fates. SpOtx was found in th...

aims: fatalistic employees take serious risks because they have limited knowledge of risks and accidents, leading them to under estimate the possibility of their occurrence. this research examined the effectiveness of safety training on changing employees’ fatalism with attention to the mediating role of attitude toward safety issues. methods: 204 employees was selected according to the stratif...

BACKGROUND In preimplantation mouse embryos, the first cell fate specification to the trophectoderm or inner cell mass occurs by the early blastocyst stage. The cell fate is controlled by cell position-dependent Hippo signaling, although the mechanisms underlying position-dependent Hippo signaling are unknown. RESULTS We show that a combination of cell polarity and cell-cell adhesion establis...

Within populations of cells, fate decisions are controlled by an indeterminate combination of cell-intrinsic and cell-extrinsic factors. In the case of stem cells, the stem cell niche is believed to maintain 'stemness' through communication and interactions between the stem cells and one or more other cell-types that contribute to the niche conditions. To investigate the robustness of cell fate...

Biological clocks play key roles in organismal development, homeostasis and function. In recent years, much work has focused on circadian clocks, but emerging studies have highlighted the existence of ultradian oscillators - those with a much shorter periodicity than 24 h. Accumulating evidence, together with recently developed optogenetic approaches, suggests that such ultradian oscillators pl...

Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are nece...

Nine demographic variables were correlated with the degree of emotional disturbance in a college population as measured by the Health Opinion Survey (HOS) which was mailed to 2800 randomly selected univer­ sity students. The number of returned questionnaires totaled 1429, yielding a return fate of 53 percent. Sex, employment, and religion were significantly correlated with emotional disturbance...

While Staphylococcus aureus accelerates human neutrophil cell death, the underlying host- and pathogen-derived mechanisms remain incompletely defined. Previous studies demonstrated that the S. aureus SaeR/S sensory system is essential for pathogen survival following neutrophil phagocytosis. Herein, we demonstrate that the SaeR/S system promoted accelerated cell death, suppressed phosphorylation...

door ir. Geert BOEIJE Thesis submitted in fulfillment of the requirements for the degree of Doctor (Ph.D) in Applied Biological Sciences Proefschrift voorgedragen tot het bekomen van de graad van Doctor in de Toegepaste Biologische Wetenschappen op gezag van